5-(dimethoxymethyl)-4-phenylpyrazole

Base Information

Chemical Name:5-(dimethoxymethyl)-4-phenylpyrazole
CAS No.:1313431-98-9
Molecular Formula:C₁₂H₁₄N₂O₂
Molecular Weight:218.255
Hs Code.:

Synonyms:

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Chemical Property of 5-(dimethoxymethyl)-4-phenylpyrazole

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Technology Process of 5-(dimethoxymethyl)-4-phenylpyrazole

There total 6 articles about 5-(dimethoxymethyl)-4-phenylpyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103-82-2
phenylacetic acid

: 1313431-98-9
5-(dimethoxymethyl)-4-phenylpyrazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N-dimethyl-formamide; trichlorophosphate / 3 h / 85 °C

1.2: Cooling with ice

2.1: sodium hydroxide / water / 50 °C

2.2: pH 5

3.1: trifluoroacetic acid / toluene / 3 h / 90 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -70 °C / Inert atmosphere

4.2: 1 h / 20 °C

4.3: 0.17 h

5.1: hydrogenchloride / methanol; water / 1 h

6.1: copper(II) tetrafluoroborate hydrate / methanol

With hydrogenchloride; n-butyllithium; copper(II) tetrafluoroborate hydrate; N,N-dimethyl-formamide; trifluoroacetic acid; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; hexane; water; toluene; 1.1: Vilsmeier reaction;
DOI:10.1039/c0nj00774a

Reference yield:

: 4-phenyl-1-(tetrahydro-2H-2-pyranyl)-1H-pyrazole

: 1313431-98-9
5-(dimethoxymethyl)-4-phenylpyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -70 °C / Inert atmosphere

1.2: 1 h / 20 °C

1.3: 0.17 h

2.1: hydrogenchloride / methanol; water / 1 h

3.1: copper(II) tetrafluoroborate hydrate / methanol

With hydrogenchloride; n-butyllithium; copper(II) tetrafluoroborate hydrate; In tetrahydrofuran; methanol; hexane; water;
DOI:10.1039/c0nj00774a

Reference yield:

: 10199-68-5
4-phenyl-1H-pyrazole

: 1313431-98-9
5-(dimethoxymethyl)-4-phenylpyrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / toluene / 3 h / 90 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -70 °C / Inert atmosphere

2.2: 1 h / 20 °C

2.3: 0.17 h

3.1: hydrogenchloride / methanol; water / 1 h

4.1: copper(II) tetrafluoroborate hydrate / methanol

With hydrogenchloride; n-butyllithium; copper(II) tetrafluoroborate hydrate; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; water; toluene;
DOI:10.1039/c0nj00774a