Technology Process of 20-epi-25-hydroxyvitamin D3
There total 10 articles about 20-epi-25-hydroxyvitamin D3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(8E,20S)-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylene-des-A,B-cholestan-25-ol; (5S)-(tert-butyldimethylsilyloxy)oct-1-en-7-yn-2-yl trifluoromethane sulfonate;
With
bis-triphenylphosphine-palladium(II) chloride; potassium phosphate;
In
tetrahydrofuran; water;
at 20 ℃;
for 0.5h;
With
hydrogen fluoride;
In
dichloromethane; acetonitrile;
at 20 ℃;
for 5h;
stereoselective reaction;
DOI:10.1002/chem.201705656
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: zinc; nickel(II) chloride hexahydrate; pyridine / 2 h / 60 °C
1.2: 4 h / 0 - 20 °C
2.1: diethyl ether; tetrahydrofuran / 3.25 h / 0 - 20 °C
3.1: hydrogen fluoride / dichloromethane; acetonitrile
4.1: dipyridinium dichromate / dichloromethane / 5 h / 20 °C
5.1: potassium tert-butylate / tetrahydrofuran; toluene / 2 h / -17 - 20 °C
5.2: 3.5 h / -17 - 20 °C
6.1: tricyclohexylphosphine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / dimethyl sulfoxide / 2 h / 80 °C
7.1: bis-triphenylphosphine-palladium(II) chloride; potassium phosphate / tetrahydrofuran; water / 0.5 h / 20 °C
7.2: 5 h / 20 °C
With
pyridine; bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; dipyridinium dichromate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; nickel(II) chloride hexahydrate; hydrogen fluoride; potassium tert-butylate; potassium acetate; zinc; tricyclohexylphosphine;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile;
7.1: |Suzuki-Miyaura Coupling;
DOI:10.1002/chem.201705656
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 1H-imidazole; triphenylphosphine; iodine / 1.08 h / -20 - 20 °C
2.1: zinc; nickel(II) chloride hexahydrate; pyridine / 2 h / 60 °C
2.2: 4 h / 0 - 20 °C
3.1: diethyl ether; tetrahydrofuran / 3.25 h / 0 - 20 °C
4.1: hydrogen fluoride / dichloromethane; acetonitrile
5.1: dipyridinium dichromate / dichloromethane / 5 h / 20 °C
6.1: potassium tert-butylate / tetrahydrofuran; toluene / 2 h / -17 - 20 °C
6.2: 3.5 h / -17 - 20 °C
7.1: tricyclohexylphosphine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / dimethyl sulfoxide / 2 h / 80 °C
8.1: bis-triphenylphosphine-palladium(II) chloride; potassium phosphate / tetrahydrofuran; water / 0.5 h / 20 °C
8.2: 5 h / 20 °C
With
pyridine; 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; dipyridinium dichromate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; nickel(II) chloride hexahydrate; hydrogen fluoride; potassium tert-butylate; iodine; potassium acetate; triphenylphosphine; zinc; tricyclohexylphosphine;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile;
8.1: |Suzuki-Miyaura Coupling;
DOI:10.1002/chem.201705656
