38-(3,5-Dimethylphenyl)-7,8,19,20,28,29,35,36-octahydro-6H,10H,16H,18H,32H,34H-59:17,21-dimethano-11,15-metheno-1,2,5-<1',3'>pyrimidino-5H,27H-dibenzo<1,23,4,8,16,20>dioxatetraazacyclohexacosine-32,37,39-trione

Base Information

Chemical Name:38-(3,5-Dimethylphenyl)-7,8,19,20,28,29,35,36-octahydro-6H,10H,16H,18H,32H,34H-59:17,21-dimethano-11,15-metheno-1,2,5-<1',3'>pyrimidino-5H,27H-dibenzo<1,23,4,8,16,20>dioxatetraazacyclohexacosine-32,37,39-trione
CAS No.:105373-36-2
Molecular Formula:C₄₃H₄₆N₆O₅
Molecular Weight:726.875
Hs Code.:

38-(3,5-Dimethylphenyl)-7,8,19,20,28,29,35,36-octahydro-6H,10H,16H,18H,32H,34H-59:17,21-dimethano-11,15-metheno-1,2,5-<1',3'>pyrimidino-5H,27H-dibenzo<b,u><1,23,4,8,16,20>dioxatetraazacyclohexacosine-32,37,39-trione

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Chemical Property of 38-(3,5-Dimethylphenyl)-7,8,19,20,28,29,35,36-octahydro-6H,10H,16H,18H,32H,34H-59:17,21-dimethano-11,15-metheno-1,2,5-<1',3'>pyrimidino-5H,27H-dibenzo<1,23,4,8,16,20>dioxatetraazacyclohexacosine-32,37,39-trione

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Technology Process of 38-(3,5-Dimethylphenyl)-7,8,19,20,28,29,35,36-octahydro-6H,10H,16H,18H,32H,34H-59:17,21-dimethano-11,15-metheno-1,2,5-<1',3'>pyrimidino-5H,27H-dibenzo<1,23,4,8,16,20>dioxatetraazacyclohexacosine-32,37,39-trione

There total 16 articles about 38-(3,5-Dimethylphenyl)-7,8,19,20,28,29,35,36-octahydro-6H,10H,16H,18H,32H,34H-59:17,21-dimethano-11,15-metheno-1,2,5-<1',3'>pyrimidino-5H,27H-dibenzo<1,23,4,8,16,20>dioxatetraazacyclohexacosine-32,37,39-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107913-47-3
1,3-Bis(2-methoxy-3-nitrophenyl)urea

: 105373-36-2,107983-32-4,107983-33-5
38-(3,5-Dimethylphenyl)-7,8,19,20,28,29,35,36-octahydro-6H,10H,16H,18H,32H,34H-59:17,21-dimethano-11,15-metheno-1,2,5-<1',3'>pyrimidino-5H,27H-dibenzo<1,23,4,8,16,20>dioxatetraazacyclohexacosine-32,37,39-trione

Guidance literature:: Multi-step reaction with 7 steps

1: 58 percent / NaOH / Bu₄N⁺I^- / benzene; H₂O / 46 °C

2: 88 percent / 48percent HBr / acetic acid / 1.5 h / Heating

3: 73 percent / anhydrous K₂CO₃ / dimethylformamide / 115 °C

4: 80 percent / tin metal / ethanol; aq. HCl / 1 h / Heating

5: 96 percent / CH₂Cl₂ / 72 h

6: 60 percent / KOH / benzyltriethylammonium bromide / tetrahydrofuran; H₂O / 192 h / 25 °C

7: NaH / tetrahydrofuran / 1.) -78 deg C, 2 h, 2.) 25 deg C, 24 h, 3.) reflux, 2 h

With potassium hydroxide; sodium hydroxide; tin; hydrogen bromide; sodium hydride; potassium carbonate; benzyltriethylammonium bromide; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; hydrogenchloride; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja00244a037

Reference yield:

: 107913-53-1
7,8,16,17-Tetrahydro-4,10-diamino-15H-14,18-methano-6H,14H-dibenzo<1,11,4,8>dioxadiazacyclotetradecan-19-one

: 105373-36-2,107983-32-4,107983-33-5
38-(3,5-Dimethylphenyl)-7,8,19,20,28,29,35,36-octahydro-6H,10H,16H,18H,32H,34H-59:17,21-dimethano-11,15-metheno-1,2,5-<1',3'>pyrimidino-5H,27H-dibenzo<1,23,4,8,16,20>dioxatetraazacyclohexacosine-32,37,39-trione

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / CH₂Cl₂ / 72 h

2: 60 percent / KOH / benzyltriethylammonium bromide / tetrahydrofuran; H₂O / 192 h / 25 °C

3: NaH / tetrahydrofuran / 1.) -78 deg C, 2 h, 2.) 25 deg C, 24 h, 3.) reflux, 2 h

With potassium hydroxide; sodium hydride; benzyltriethylammonium bromide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ja00244a037

Reference yield:

: 107913-49-5
1,3-Bis(2-hydroxy-3-nitrophenyl)tetrahydro-2-pyrimidinone

: 105373-36-2,107983-32-4,107983-33-5
38-(3,5-Dimethylphenyl)-7,8,19,20,28,29,35,36-octahydro-6H,10H,16H,18H,32H,34H-59:17,21-dimethano-11,15-metheno-1,2,5-<1',3'>pyrimidino-5H,27H-dibenzo<1,23,4,8,16,20>dioxatetraazacyclohexacosine-32,37,39-trione

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / anhydrous K₂CO₃ / dimethylformamide / 115 °C

2: 80 percent / tin metal / ethanol; aq. HCl / 1 h / Heating

3: 96 percent / CH₂Cl₂ / 72 h

4: 60 percent / KOH / benzyltriethylammonium bromide / tetrahydrofuran; H₂O / 192 h / 25 °C

5: NaH / tetrahydrofuran / 1.) -78 deg C, 2 h, 2.) 25 deg C, 24 h, 3.) reflux, 2 h

With potassium hydroxide; tin; sodium hydride; potassium carbonate; benzyltriethylammonium bromide; In tetrahydrofuran; hydrogenchloride; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ja00244a037