2-{(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-[(1S)-1-methylpropyl]-2,5-dioxo-1-piperazinyl}-2-(2,5-dimethyl-3-pyridinyl)-N-(2-hydroxyphenyl)acetamide

Base Information

Chemical Name:2-{(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-[(1S)-1-methylpropyl]-2,5-dioxo-1-piperazinyl}-2-(2,5-dimethyl-3-pyridinyl)-N-(2-hydroxyphenyl)acetamide
CAS No.:1354788-64-9
Molecular Formula:C₃₂H₃₆N₄O₄
Molecular Weight:540.662
Hs Code.:

2-{(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-[(1S)-1-methylpropyl]-2,5-dioxo-1-piperazinyl}-2-(2,5-dimethyl-3-pyridinyl)-N-(2-hydroxyphenyl)acetamide

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Chemical Property of 2-{(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-[(1S)-1-methylpropyl]-2,5-dioxo-1-piperazinyl}-2-(2,5-dimethyl-3-pyridinyl)-N-(2-hydroxyphenyl)acetamide

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Technology Process of 2-{(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-[(1S)-1-methylpropyl]-2,5-dioxo-1-piperazinyl}-2-(2,5-dimethyl-3-pyridinyl)-N-(2-hydroxyphenyl)acetamide

There total 5 articles about 2-{(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-[(1S)-1-methylpropyl]-2,5-dioxo-1-piperazinyl}-2-(2,5-dimethyl-3-pyridinyl)-N-(2-hydroxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₈H₅₂N₄O₇

: 1354788-64-9
2-{(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-[(1S)-1-methylpropyl]-2,5-dioxo-1-piperazinyl}-2-(2,5-dimethyl-3-pyridinyl)-N-(2-hydroxyphenyl)acetamide

Guidance literature:: With palladium on activated charcoal; hydrogen; In ethanol; water; acetic acid; for 18h; under 760.051 Torr;
DOI:10.1021/jm201287w

Reference yield:

: 554448-74-7
(2R)-2,3-dihydro-1H-inden-2-yl({[(phenylmethyl)oxy]carbonyl}amino)ethanoic acid

: 1354788-64-9
2-{(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-[(1S)-1-methylpropyl]-2,5-dioxo-1-piperazinyl}-2-(2,5-dimethyl-3-pyridinyl)-N-(2-hydroxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / methanol; 2,2,2-trifluoroethanol / 20 h / 20 °C / Inert atmosphere

1.2: 96 h / 20 °C / Inert atmosphere

2.1: palladium on activated charcoal; hydrogen / ethanol; water; acetic acid / 18 h / 760.05 Torr

With palladium on activated charcoal; hydrogen; triethylamine; In methanol; ethanol; 2,2,2-trifluoroethanol; water; acetic acid; 1.1: Ugi condensation / 1.2: Ugi condensation;
DOI:10.1021/jm201287w

Reference yield:

: 4-phenyl-3,4,6a,11,11a,11b-hexahydro-1H-indeno[2,1:4,5]isoxazolo[3,2-c][1,4]oxazin-1-one

: 1354788-64-9
2-{(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-[(1S)-1-methylpropyl]-2,5-dioxo-1-piperazinyl}-2-(2,5-dimethyl-3-pyridinyl)-N-(2-hydroxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 20 % Pd(OH)2/C; hydrogen / 1,4-dioxane; trifluoroacetic acid / 55 °C / 3102.97 Torr

2.1: triethylamine / 1,4-dioxane; water / 48 h / 20 °C

3.1: triethylamine / methanol; 2,2,2-trifluoroethanol / 20 h / 20 °C / Inert atmosphere

3.2: 96 h / 20 °C / Inert atmosphere

4.1: palladium on activated charcoal; hydrogen / ethanol; water; acetic acid / 18 h / 760.05 Torr

With palladium on activated charcoal; 20 % Pd(OH)2/C; hydrogen; triethylamine; In 1,4-dioxane; methanol; ethanol; 2,2,2-trifluoroethanol; water; acetic acid; trifluoroacetic acid; 3.1: Ugi condensation / 3.2: Ugi condensation;
DOI:10.1021/jm201287w