Furo[3,2-b]pyridine-2-carboxylic acid

Base Information

• Chemical Name: Furo[3,2-b]pyridine-2-carboxylic acid
• CAS No.: 112372-14-2
• Molecular Formula: C8H5NO3
• Molecular Weight: 163.133
• European Community (EC) Number: 691-921-2
• DSSTox Substance ID: DTXSID70549936
• Wikidata: Q82429129
• Mol file: 112372-14-2.mol

Synonyms:furo[3,2-b]pyridine-2-carboxylic acid;112372-14-2;OTAVA-BB 1199329;2-carboxyfuro[3,2-b]pyridine;SCHEMBL4128614;DTXSID70549936;VHRCHODSRLMXFM-UHFFFAOYSA-N;MFCD11588128;AKOS005208159;furo[3,2-b]pyridine-2-carboxylicacid;SB73832;AS-56810;CS-0106542;D76647;EN300-241660;Z2670715454

Chemical Property of Furo[3,2-b]pyridine-2-carboxylic acid

Chemical Property:

• Melting Point: >300℃
• Boiling Point: 332.6±22.0 °C(Predicted)
• PKA: 1.60±0.30(Predicted)
• PSA: 63.33000
• Density: 1.455±0.06 g/cm3(Predicted)
• LogP: 1.52600
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 163.026943022
• Heavy Atom Count: 12
• Complexity: 195

Purity/Quality:

97% ^*data from raw suppliers

Furo[3,2-b]pyridine-2-carboxylicacid 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=C(O2)C(=O)O)N=C1

Technology Process of Furo[3,2-b]pyridine-2-carboxylic acid

There total 4 articles about Furo[3,2-b]pyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-cyanofuro<3,2-b>pyridine (112372-11-9) → furo<3,2-b>pyridine-2-carboxylic acid (112372-14-2)

Guidance literature:

With potassium hydroxide; In ethanol; for 2h; Heating;

Reference yield:

furo[3,2-b]pyridine (272-62-8) → furo<3,2-b>pyridine-2-carboxylic acid (112372-14-2)

Guidance literature:

Multi-step reaction with 4 steps

2: 91 percent / hydroxylamine hydrochloride, K₂CO₃ / aq. ethanol / 2 h / Ambient temperature

3: 64 percent / 2,4,6-trichloro-s-triazine, pyridine / CH₂Cl₂ / 1.5 h / Heating

4: 95 percent / KOH / aq. ethanol / 2 h / Heating

With pyridine; potassium hydroxide; 1,3,5-trichloro-2,4,6-triazine; hydroxylamine hydrochloride; potassium carbonate; In ethanol; dichloromethane;

Reference yield:

2-formylfuro<3,2-b>pyridine (112372-05-1) → furo<3,2-b>pyridine-2-carboxylic acid (112372-14-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / hydroxylamine hydrochloride, K₂CO₃ / aq. ethanol / 2 h / Ambient temperature

2: 64 percent / 2,4,6-trichloro-s-triazine, pyridine / CH₂Cl₂ / 1.5 h / Heating

3: 95 percent / KOH / aq. ethanol / 2 h / Heating

With pyridine; potassium hydroxide; 1,3,5-trichloro-2,4,6-triazine; hydroxylamine hydrochloride; potassium carbonate; In ethanol; dichloromethane;

upstream raw materials:

2-cyanofuro<3,2-b>pyridine

furo[3,2-b]pyridine

2-formylfuro<3,2-b>pyridine

Furo[3,2-b]pyridine-2-carbaldehyde oxime

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