5-methyl-2,3-diphenyl-1-benzofuran

Base Information

• Chemical Name: 5-methyl-2,3-diphenyl-1-benzofuran
• CAS No.: 6723-06-4
• Molecular Formula: C21H16 O
• Molecular Weight: 284.357
• Mol file: 6723-06-4.mol

Synonyms:5-Methyl-2,3-diphenylbenzofuran;5-Methyl-2,3-diphenylcoumarone; NSC 76703

Chemical Property of 5-methyl-2,3-diphenyl-1-benzofuran

Chemical Property:

• Vapor Pressure: 9.87E-07mmHg at 25°C
• Boiling Point: 415.5°C at 760 mmHg
• Flash Point: 212.1°C
• Density: 1.123g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-methyl-2,3-diphenyl-1-benzofuran

There total 9 articles about 5-methyl-2,3-diphenyl-1-benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

p-cresol (106-44-5) + diphenyl acetylene (501-65-5) → 2,3-diphenyl-5-methylbenzofuran (6723-06-4)

Guidance literature:

With oxygen; copper(II) bis(trifluoromethanesulfonate); zinc(II) chloride; In nitrobenzene; at 120 ℃; for 24h; Schlenk technique;

DOI:10.1039/c3cc42326c

Reference yield: 88.0%

diphenyl acetylene (501-65-5) + N-(4-methylphenoxy)acetamide → 2,3-diphenyl-5-methylbenzofuran (6723-06-4)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; acetic acid; In dichloromethane; at 20 ℃;

DOI:10.1002/anie.201300881

Reference yield: 83.0%

phenylacetic acid (103-82-2) + 2-hydroxy-5-methylbenzophenone (1470-57-1) → 2,3-diphenyl-5-methylbenzofuran (6723-06-4) + 6-methyl-3,4-diphenyl-2H-chromen-2-one (33257-85-1)

Guidance literature:

In diphenylether; for 16h; Heating;

upstream raw materials:

phenylacetic acid

2-hydroxy-5-methylbenzophenone

p-cresol

diphenyl acetylene

Downstream raw materials:

6-(2',3'-diphenyl-5'-methyl-6'-benzofuranyl)-3-(O-benzenesulphonyl)-4,5-dihydropyridazine

1-benzenesulphonyl-6-(2',3'-diphenyl-5'-methyl-6'-benzofuranyl)-2,3,4,5-tetrahydropyridazine-3-one

4-[(Z)-2-Hydroxy-phenylimino]-4-(5-methyl-2,3-diphenyl-benzofuran-6-yl)-butyric acid ethyl ester

6-(5-Methyl-2,3-diphenyl-benzofuran-6-yl)-2-morpholin-4-ylmethyl-4,5-dihydro-2H-pyridazin-3-one

Refernces

• 1、 Liao, Jinqiang,Guo, Pengfeng,Chen, Qinlin. "Au-catalyzed synthesis of benzofurans from phenols and alkynes using molecular oxygen". . p. 22 - 25. Retrieved 2016/02/19.
• 2、 Han, Jiang-Sheng,Chen, Su-Qin,Zhong, Ping,Zhang, Xiao-Hong. "One-pot synthesis of 2,3-diarylbenzofurans via sequential iodocyclization and Pd-catalyzed Suzuki coupling reactions of 2-alkynylanisoles with boronic acids in water". supporting information. p. 3148 - 3155. Retrieved 2015/10/06.