33257-85-1

Basic information

• Product Name: 6-methyl-3,4-diphenyl-2H-chromen-2-one
• Synonyms: 6-methyl-3,4-diphenyl-2H-chromen-2-one
• CAS NO: 33257-85-1
• Molecular Weight: 312.368
• Mol File: 33257-85-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 6-methyl-3,4-diphenyl-2H-chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methyl-3,4-diphenyl-2H-chromen-2-one(33257-85-1)
• EPA Substance Registry System: 6-methyl-3,4-diphenyl-2H-chromen-2-one(33257-85-1)

Safety Data

• Hazardous Substances Data: 33257-85-1(Hazardous Substances Data)

Upstream product

• 1470-57-1 2-hydroxy-5-methylbenzophenone 
• 16241-02-4 O-(4-methylphenyl) N,N-dimethylthiocarbamate 
• 501-65-5 diphenyl acetylene 
• 140-39-6 1-acetoxy-4-methylbenzene 
• 614-34-6 p-cresyl benzoate 
• 140-29-4 phenylacetonitrile 
• 4072-13-3 (2-methoxy-5-methylphenyl)phenylmethanone 
• 2431-96-1 N,N-diethylphenylacetamide 
• 103-82-2 phenylacetic acid 
• 1555-80-2 phenylacetic anhydride 
• 121360-54-1 5-methyl-2-phenylacetoxybenzophenone 

Downstream Products

• 345313-80-6 2,3-diphenyl-3-(2-hydroxy-5-methylphenyl)propanol-1 
• 81009-04-3 2-((Z)-3-Hydroxy-1,2-diphenyl-propenyl)-4-methyl-phenol 
• 18435-82-0 6-methyl-3,4-diphenylchroman-2-one 
• 18435-82-0 6-methyl-3,4-diphenylchroman-2-one 
• 117319-82-1 6-Methyl-3,4-diphenyl-2H-chromene 
• 861781-24-0 6-methyl-2,3,4-triphenyl-2H-chromen-2-ol 

Relevant articles and documents

A coumarin derivative synthesis method

The invention relates to a synthesis method of coumarin derivatives disclosed as Formula (III), which comprises the following steps: in a nitrogen atmosphere, adding compounds disclosed as Formula (I), compounds disclosed as Formula (II), a catalyst, an accelerator and an assistant into an organic solvent, stirring to react at 70-90 DEG C for 5-8 hours, and carrying out after-treatment to obtain the compounds disclosed as Formula (III), wherein R1 and R2 are respectively and independently selected from H, C1-C6 alkyl group or halogen; R3 and R4 are respectively and independently selected from C1-C6 alkyl group, unsubstituted phenyl group or phenyl group with substituent group (C1-C6 alkoxy group or halogen). Under the combined selection and synergic actions of the catalyst, accelerator, assistant and organic solvent, the high-yield target product can be obtained. The coumarin derivatives have wide industrial application value and production potential in the field of organic synthesis and especially the field of drug intermediate synthesis.

A facile synthesis of highly functionalized 4-arylcoumarins via kostanecki reactions mediated by DBU

An efficient synthesis of 4-arylcoumarins has been accomplished via Kostanecki reactions of 2-hydroxybenzophenones with acetic anhydride employing DBU at ambient temperature. Using the same strategy, several 2-acyloxybenzophenone derivatives were readily converted to 3,4-difunctionalized coumarins. This protocol offers a notable improvement in reaction conditions for coumarin synthesis and takes advantage of its synthetic capability, especially for highly functionalized 4-arylcoumarins with structural diversity.

Ac2O/Et3N Induced Condensation of o-Hydroxybenzophenone with Phenylacetic Acid: A Study of the Mechanism of Coumarin Formation

The mechanism of coumarin formation from o-hydroxybenzophenone and phenylacetic acid in the presence of Ac2O/Et3N has been investigated.Intermolecular hydrogen bonding of o-hydroxy leads to partial carbonium ion formation thereby facilitating nucleophilic