C₂₆H₂₄F₉N₁₁O₂

Base Information

• Chemical Name: C₂₆H₂₄F₉N₁₁O₂
• CAS No.: 867012-10-0
• Molecular Formula: C₂₆H₂₄F₉N₁₁O₂
• Molecular Weight: 693.535
• Mol file: 867012-10-0.mol

Synonyms:

Chemical Property of C₂₆H₂₄F₉N₁₁O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₂₄F₉N₁₁O₂

There total 10 articles about C₂₆H₂₄F₉N₁₁O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C3H6N4O (17587-08-5) + C23H19ClF9N7O (867012-73-5) → C26H24F9N11O2 (867012-10-0)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 20h;

DOI:10.1016/j.bmcl.2012.03.075

Reference yield:

C13H16F3N3O → C26H24F9N11O2 (867012-10-0)

Guidance literature:

Multi-step reaction with 10 steps

1: pyridine / 0 - 20 °C

2: hydrogenchloride / water / 80 °C

3: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

5: sodium azide; triethylamine / toluene / 110 °C

6: potassium carbonate / acetonitrile

7: Chiralpak AD / Resolution of racemate

8: sulfuric acid; trifluoroacetic acid / 0 - 20 °C

9: triethylamine / toluene

10: dmap / dichloromethane / 20 h / 20 °C

With pyridine; hydrogenchloride; dmap; sodium azide; sulfuric acid; sodium tris(acetoxy)borohydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; toluene; acetonitrile;

DOI:10.1016/j.bmcl.2012.03.075

Reference yield:

C24H24F9N3O2 → C26H24F9N11O2 (867012-10-0)

Guidance literature:

Multi-step reaction with 7 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

2: sodium azide; triethylamine / toluene / 110 °C

3: potassium carbonate / acetonitrile

4: Chiralpak AD / Resolution of racemate

5: sulfuric acid; trifluoroacetic acid / 0 - 20 °C

6: triethylamine / toluene

7: dmap / dichloromethane / 20 h / 20 °C

With dmap; sodium azide; sulfuric acid; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;

DOI:10.1016/j.bmcl.2012.03.075

upstream raw materials:

C₂₂H₂₀F₉N₇

(2R,4S)-isopropyl 4-((3,5-bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-1,5-naphthyridine-1(2H)-carboxylate.

C₃H₆N₄O

C₂₃H₁₉ClF₉N₇O