(1S,3aR,6aS)-2-[(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid ethyl ester

Base Information

Chemical Name:(1S,3aR,6aS)-2-[(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid ethyl ester
CAS No.:402958-48-9
Molecular Formula:C₃₅H₅₃N₇O₅
Molecular Weight:651.85
Hs Code.:

(1S,3aR,6aS)-2-[(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid ethyl ester

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Chemical Property of (1S,3aR,6aS)-2-[(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid ethyl ester

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Technology Process of (1S,3aR,6aS)-2-[(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid ethyl ester

There total 6 articles about (1S,3aR,6aS)-2-[(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 402958-25-2,864185-81-9
(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate

: 402958-47-8
(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyric acid

: 402958-48-9
(1S,3aR,6aS)-2-[(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid ethyl ester

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; dicyclohexyl-carbodiimide;
DOI:10.1016/j.bmcl.2004.05.078

Reference yield:

: 3009-88-9
5-cyanopentanoic acid methyl ester

: 402958-48-9
(1S,3aR,6aS)-2-[(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 68 percent / NaN₃; Et₃N*HCl

2: 95 percent / Cl₃CCO₂H

3: 75 percent / aq. NaOH

4: 75 percent / EDCI; DIEA

5: 91 percent / DIEA

6: 58 percent / HOAt; DCC

With sodium hydroxide; sodium azide; 1-hydroxy-7-aza-benzotriazole; triethylamine hydrochloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trichloroacetic acid;
DOI:10.1016/j.bmcl.2004.05.078

Reference yield:

: 80486-64-2
methyl 5-(1,2,3,4-tetrazol-5-yl)valerate

: 402958-48-9
(1S,3aR,6aS)-2-[(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / Cl₃CCO₂H

2: 75 percent / aq. NaOH

3: 75 percent / EDCI; DIEA

4: 91 percent / DIEA

5: 58 percent / HOAt; DCC

With sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trichloroacetic acid;
DOI:10.1016/j.bmcl.2004.05.078