(1S,3aR,6aS)-2-[(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid

Base Information

• Chemical Name: (1S,3aR,6aS)-2-[(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid
• CAS No.: 402958-49-0
• Molecular Formula: C₃₃H₄₉N₇O₅
• Molecular Weight: 623.796
• Mol file: 402958-49-0.mol

Synonyms:

Chemical Property of (1S,3aR,6aS)-2-[(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,3aR,6aS)-2-[(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid

There total 8 articles about (1S,3aR,6aS)-2-[(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1S,3aR,6aS)-2-[(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid ethyl ester (402958-48-9) → (1S,3aR,6aS)-2-[(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid (402958-49-0)

Guidance literature:

With sodium hydroxide;

DOI:10.1016/j.bmcl.2004.05.078

Reference yield:

5-cyanopentanoic acid methyl ester (3009-88-9) → (1S,3aR,6aS)-2-[(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid (402958-49-0)

Guidance literature:

Multi-step reaction with 7 steps

1: 68 percent / NaN₃; Et₃N*HCl

2: 95 percent / Cl₃CCO₂H

3: 75 percent / aq. NaOH

4: 75 percent / EDCI; DIEA

5: 91 percent / DIEA

6: 58 percent / HOAt; DCC

7: 100 percent / aq. NaOH

With sodium hydroxide; sodium azide; 1-hydroxy-7-aza-benzotriazole; triethylamine hydrochloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trichloroacetic acid;

DOI:10.1016/j.bmcl.2004.05.078

Reference yield:

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate (402958-25-2,864185-81-9) → (1S,3aR,6aS)-2-[(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid (402958-49-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / HOAt; DCC

2: 100 percent / aq. NaOH

With sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; dicyclohexyl-carbodiimide;

DOI:10.1016/j.bmcl.2004.05.078

upstream raw materials:

(1S,3aR,6aS)-2-[(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid ethyl ester

5-cyanopentanoic acid methyl ester

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate

methyl 5-(1,2,3,4-tetrazol-5-yl)valerate

Downstream raw materials:

(1S,3aR,6aS)-2-[(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid [1-(cyclopropylcarbamoyl-hydroxy-methyl)-butyl]-amide