3-[N-(2,2-diethoxyethyl)-N-p-tosylaminomethyl]-5,7-dimethoxy-1,4-dimethylcarbazole

Base Information

• Chemical Name: 3-[N-(2,2-diethoxyethyl)-N-p-tosylaminomethyl]-5,7-dimethoxy-1,4-dimethylcarbazole
• CAS No.: 176385-67-4
• Molecular Formula: C₃₀H₃₈N₂O₆S
• Molecular Weight: 554.708
• Mol file: 176385-67-4.mol

Synonyms:

Chemical Property of 3-[N-(2,2-diethoxyethyl)-N-p-tosylaminomethyl]-5,7-dimethoxy-1,4-dimethylcarbazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[N-(2,2-diethoxyethyl)-N-p-tosylaminomethyl]-5,7-dimethoxy-1,4-dimethylcarbazole

There total 13 articles about 3-[N-(2,2-diethoxyethyl)-N-p-tosylaminomethyl]-5,7-dimethoxy-1,4-dimethylcarbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

p-toluenesulfonyl chloride (98-59-9) + 3-(2,2-diethoxyethylaminomethyl)-5,7-dimethoxy-1,4-dimethylcarbazole (176385-66-3) → 3-[N-(2,2-diethoxyethyl)-N-p-tosylaminomethyl]-5,7-dimethoxy-1,4-dimethylcarbazole (176385-67-4)

Guidance literature:

With pyridine; at 20 ℃; for 41h;

Reference yield:

1-bromo-3,5-dimethoxybenzene (20469-65-2) → 3-[N-(2,2-diethoxyethyl)-N-p-tosylaminomethyl]-5,7-dimethoxy-1,4-dimethylcarbazole (176385-67-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 72 percent / Cu₂O, K₂CO₃ / 8 h / 200 °C

2: 98 percent / aq. KOH / ethanol / 0.25 h / Heating

3: 32 percent / palladium(II) acetate, AcOH / 2 h / Heating

4: 1.) diisobutylaluminum hydride, 2.) 2 M HCl / 1.) diglyme, toluene, a) -70 deg C, 0.5 h, b) 20 deg C, 2 h, 2.) MeOH, RT, 2 h

5: 100 percent / toluene / 2.5 h / Heating

6: 100 percent / H₂ / PtO₂ / ethanol / 20 °C / 760 Torr

7: 65 percent / pyridine / 41 h / 20 °C

With pyridine; copper(I) oxide; hydrogenchloride; potassium hydroxide; hydrogen; palladium diacetate; diisobutylaluminium hydride; potassium carbonate; acetic acid; platinum(IV) oxide; In ethanol; toluene;

Reference yield:

4-cyano-2,5-dimethylacetanilide (94881-68-2) → 3-[N-(2,2-diethoxyethyl)-N-p-tosylaminomethyl]-5,7-dimethoxy-1,4-dimethylcarbazole (176385-67-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 72 percent / Cu₂O, K₂CO₃ / 8 h / 200 °C

2: 98 percent / aq. KOH / ethanol / 0.25 h / Heating

3: 32 percent / palladium(II) acetate, AcOH / 2 h / Heating

4: 1.) diisobutylaluminum hydride, 2.) 2 M HCl / 1.) diglyme, toluene, a) -70 deg C, 0.5 h, b) 20 deg C, 2 h, 2.) MeOH, RT, 2 h

5: 100 percent / toluene / 2.5 h / Heating

6: 100 percent / H₂ / PtO₂ / ethanol / 20 °C / 760 Torr

7: 65 percent / pyridine / 41 h / 20 °C

With pyridine; copper(I) oxide; hydrogenchloride; potassium hydroxide; hydrogen; palladium diacetate; diisobutylaluminium hydride; potassium carbonate; acetic acid; platinum(IV) oxide; In ethanol; toluene;

upstream raw materials:

p-toluenesulfonyl chloride

3-(2,2-diethoxyethylaminomethyl)-5,7-dimethoxy-1,4-dimethylcarbazole

1-bromo-3,5-dimethoxybenzene

4-cyano-2,5-dimethylacetanilide