5'-O-(bis<2-(p-nitrophenyl)ethyl>phosphoryl)thymidylyl(3'-P-(2-(p-nitrophenyl)ethyl)>-5')thymidine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate)

Base Information

• Chemical Name: 5'-O-(bis<2-(p-nitrophenyl)ethyl>phosphoryl)thymidylyl(3'-P-(2-(p-nitrophenyl)ethyl)>-5')thymidine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate)
• CAS No.: 85363-85-5
• Molecular Formula: C₆₀H₆₄N₉O₂₈P₃
• Molecular Weight: 1452.13
• Mol file: 85363-85-5.mol

Synonyms:

Chemical Property of 5'-O-(bis<2-(p-nitrophenyl)ethyl>phosphoryl)thymidylyl(3'-P-(2-(p-nitrophenyl)ethyl)>-5')thymidine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-(bis<2-(p-nitrophenyl)ethyl>phosphoryl)thymidylyl(3'-P-(2-(p-nitrophenyl)ethyl)>-5')thymidine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate)

There total 7 articles about 5'-O-(bis<2-(p-nitrophenyl)ethyl>phosphoryl)thymidylyl(3'-P-(2-(p-nitrophenyl)ethyl)>-5')thymidine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

thimidine 3'-(bis<2-(p-nitrophenyl)ethyl>phosphate) (85363-79-7) + 5'-O-(bis<2-(p-nitrophenyl)ethyl>phosphoryl)thymidine 3'-<(p-nitrophenyl)ethyl phosphate> (85363-83-3) → 5'-O-(bis<2-(p-nitrophenyl)ethyl>phosphoryl)thymidylyl(3'-P-(2-(p-nitrophenyl)ethyl)>-5')thymidine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate) (85363-85-5)

Guidance literature:

With pyridine; 1-methyl-1H-imidazole; 2,4,6-triisopropylphenylsulfonyl chloride; for 24h; Ambient temperature;

DOI:10.1002/hlca.19870700508

Reference yield:

bis<2-(p-nitrophenyl)ethyl> phosphorochloridate (85363-77-5) → 5'-O-(bis<2-(p-nitrophenyl)ethyl>phosphoryl)thymidylyl(3'-P-(2-(p-nitrophenyl)ethyl)>-5')thymidine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate) (85363-85-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / pyridine, N-methylimidazole / 2 h / Ambient temperature

2: 92 percent / 2percent TsOH / diethyl ether; CH₂Cl₂ / 1 h / Ambient temperature

3: 66 percent / pyridine, 2,4,6-triisopropylbenzensulfonyl chloride, N-methylimidazole / 24 h / Ambient temperature

With pyridine; 1-methyl-1H-imidazole; 2,4,6-triisopropylphenylsulfonyl chloride; toluene-4-sulfonic acid; In diethyl ether; dichloromethane;

DOI:10.1002/hlca.19870700508

Reference yield:

bis(p-nitrophenylethyl)phosphite (85363-76-4) → 5'-O-(bis<2-(p-nitrophenyl)ethyl>phosphoryl)thymidylyl(3'-P-(2-(p-nitrophenyl)ethyl)>-5')thymidine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate) (85363-85-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / SO₂Cl₂ / CCl₄; CH₂Cl₂ / 0.25 h

2: 81 percent / pyridine, N-methylimidazole / 2 h / Ambient temperature

3: 92 percent / 2percent TsOH / diethyl ether; CH₂Cl₂ / 1 h / Ambient temperature

4: 66 percent / pyridine, 2,4,6-triisopropylbenzensulfonyl chloride, N-methylimidazole / 24 h / Ambient temperature

With pyridine; 1-methyl-1H-imidazole; sulfuryl dichloride; 2,4,6-triisopropylphenylsulfonyl chloride; toluene-4-sulfonic acid; In tetrachloromethane; diethyl ether; dichloromethane;

DOI:10.1002/hlca.19870700508

upstream raw materials:

thimidine 3'-(bis<2-(p-nitrophenyl)ethyl>phosphate)

5'-O-(bis<2-(p-nitrophenyl)ethyl>phosphoryl)thymidine 3'-<(p-nitrophenyl)ethyl phosphate>

2-(4-nitrophenyl)ethanol

bis<2-(p-nitrophenyl)ethyl> phosphorochloridate

Downstream raw materials:

5'-d(TpTp)-3'