N-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-2-(4-{[4-(2-hydroxy-3-isopropylamino-propoxy)-phenylcarbamoyl]-methyl}-piperazin-1-yl)-acetamide

Base Information

Chemical Name:N-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-2-(4-{[4-(2-hydroxy-3-isopropylamino-propoxy)-phenylcarbamoyl]-methyl}-piperazin-1-yl)-acetamide
CAS No.:106163-25-1
Molecular Formula:C₃₂H₅₀N₆O₆
Molecular Weight:614.786
Hs Code.:

N-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-2-(4-{[4-(2-hydroxy-3-isopropylamino-propoxy)-phenylcarbamoyl]-methyl}-piperazin-1-yl)-acetamide

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Chemical Property of N-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-2-(4-{[4-(2-hydroxy-3-isopropylamino-propoxy)-phenylcarbamoyl]-methyl}-piperazin-1-yl)-acetamide

Chemical Property:

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Technology Process of N-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-2-(4-{[4-(2-hydroxy-3-isopropylamino-propoxy)-phenylcarbamoyl]-methyl}-piperazin-1-yl)-acetamide

There total 6 articles about N-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-2-(4-{[4-(2-hydroxy-3-isopropylamino-propoxy)-phenylcarbamoyl]-methyl}-piperazin-1-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 106191-50-8,106191-52-0
N-{4-[3-(Benzyl-isopropyl-amino)-2-hydroxy-propoxy]-phenyl}-2-[4-({4-[3-(benzyl-isopropyl-amino)-2-hydroxy-propoxy]-phenylcarbamoyl}-methyl)-piperazin-1-yl]-acetamide

: 106163-25-1,106163-39-7
N-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-2-(4-{[4-(2-hydroxy-3-isopropylamino-propoxy)-phenylcarbamoyl]-methyl}-piperazin-1-yl)-acetamide

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In methanol; Ambient temperature;
DOI:10.1021/jm00387a025

Reference yield:

: 6597-75-7
1-(4-acetamidophenoxy)-2,3-epoxypropane

: 106163-25-1,106163-39-7
N-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-2-(4-{[4-(2-hydroxy-3-isopropylamino-propoxy)-phenylcarbamoyl]-methyl}-piperazin-1-yl)-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / methanol / 5 h / Heating

2: 82.5 percent / HCl / ethanol / 5 h / Heating

3: 70 percent / triethylamine / diethyl ether / 3 h / Ambient temperature

4: 53 percent / NaI, Na₂CO₃ / ethanol / 2 h / Heating

5: 26 percent / 10percent HOAc, H₂ / 5percent Pd/C / methanol / Ambient temperature

With hydrogenchloride; hydrogen; sodium carbonate; acetic acid; triethylamine; sodium iodide; palladium on activated charcoal; In methanol; diethyl ether; ethanol;
DOI:10.1021/jm00387a025

Reference yield:

: 103-90-2,8055-08-1
4-acetaminophenol

: 106163-25-1,106163-39-7
N-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-2-(4-{[4-(2-hydroxy-3-isopropylamino-propoxy)-phenylcarbamoyl]-methyl}-piperazin-1-yl)-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 50 percent / NaOH / H₂O / 16 h / Ambient temperature

2: 89 percent / methanol / 5 h / Heating

3: 82.5 percent / HCl / ethanol / 5 h / Heating

4: 70 percent / triethylamine / diethyl ether / 3 h / Ambient temperature

5: 53 percent / NaI, Na₂CO₃ / ethanol / 2 h / Heating

6: 26 percent / 10percent HOAc, H₂ / 5percent Pd/C / methanol / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; sodium carbonate; acetic acid; triethylamine; sodium iodide; palladium on activated charcoal; In methanol; diethyl ether; ethanol; water;
DOI:10.1021/jm00387a025