6597-75-7

Basic information

• Product Name: N-(4-(OXIRANYLMETHOXY)-1,2-EPOXYPROPANE
• Synonyms: N-(4-(OXIRANYLMETHOXY)-1,2-EPOXYPROPANE;3-[(p-Acetamido)phenoxy]-1,2-epoxypropane;N-[4-(Oxiranylmethoxy)phenyl]acetamide;4-AcetaMidophenyl Glycidyl Ether;N-(4-glycidoxyphenyl)acetamide;N-[4-(2-oxiranylmethoxy)phenyl]acetamide;N-[4-(oxiran-2-ylmethoxy)phenyl]ethanamide
• CAS NO: 6597-75-7
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.23
• Product Categories: Aromatics, Heterocycles
• Mol File: 6597-75-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 122 °C
• Boiling Point: 423.4±20.0 °C(Predicted)
• Appearance: /
• Density: 1.242±0.06 g/cm3(Predicted)
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
• PKA: 14.53±0.70(Predicted)
• CAS DataBase Reference: N-(4-(OXIRANYLMETHOXY)-1,2-EPOXYPROPANE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(OXIRANYLMETHOXY)-1,2-EPOXYPROPANE(6597-75-7)
• EPA Substance Registry System: N-(4-(OXIRANYLMETHOXY)-1,2-EPOXYPROPANE(6597-75-7)

Safety Data

• Hazardous Substances Data: 6597-75-7(Hazardous Substances Data)

Usage

Chemical Properties

White Powder

Uses

4-Acetamidophenyl Glycidyl Ether is an intermediate in the preparation of cardioselective β-adrenergic receptor antagonists.

Upstream product

• 103-90-2 4-acetaminophenol 
• 106-89-8 epichlorohydrin 
• 98-95-3 nitrobenzene 
• 100-65-2 N-Phenylhydroxylamine 
• 1795-83-1 N-Phenylacetohydroxamic acid 
• 123-30-8 4-amino-phenol 
• 2623-33-8 4-acetoxyacetanilide 
• 118712-54-2 glycidyl p-toluenesulfonate 

Downstream Products

• 76805-34-0 1-(4-acetamidophenoxy)-3-{β-[N-benzyl-N-(1-methyl-2-phenoxyethyl)]aminoethyl}amino-2-propanol 
• 36793-60-9 1-[1-(4-Acetamidophenoxy)-2-hydroxyprop-3-yl]-4-benzamidopiperidine 
• 131813-57-5 N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(4-acetamidophenoxy)-propanamine 
• 131813-58-6 N-(1,2,3,4-tetrahydronaphth1-yl)-2-hydroxy-3-(4-acetamidophenoxy)propanamine 
• 106163-17-1 N-{4-[3-(Benzyl-isopropyl-amino)-2-hydroxy-propoxy]-phenyl}-2-{8-[({4-[3-(benzyl-isopropyl-amino)-2-hydroxy-propoxy]-phenylcarbamoyl}-methyl)-amino]-octylamino}-acetamide 
• 106163-16-0 N-{4-[3-(Benzyl-isopropyl-amino)-2-hydroxy-propoxy]-phenyl}-2-{6-[({4-[3-(benzyl-isopropyl-amino)-2-hydroxy-propoxy]-phenylcarbamoyl}-methyl)-amino]-hexylamino}-acetamide 
• 106191-50-8 N-{4-[3-(Benzyl-isopropyl-amino)-2-hydroxy-propoxy]-phenyl}-2-[4-({4-[3-(benzyl-isopropyl-amino)-2-hydroxy-propoxy]-phenylcarbamoyl}-methyl)-piperazin-1-yl]-acetamide 
• 106163-15-9 N-{4-[3-(Benzyl-isopropyl-amino)-2-hydroxy-propoxy]-phenyl}-2-{4-[({4-[3-(benzyl-isopropyl-amino)-2-hydroxy-propoxy]-phenylcarbamoyl}-methyl)-amino]-butylamino}-acetamide 
• 106163-14-8 Decanedioic acid bis-({4-[3-(benzyl-isopropyl-amino)-2-hydroxy-propoxy]-phenyl}-amide) 
• 106163-13-7 Octanedioic acid bis-({4-[3-(benzyl-isopropyl-amino)-2-hydroxy-propoxy]-phenyl}-amide) 
• 106163-12-6 Hexanedioic acid bis-({4-[3-(benzyl-isopropyl-amino)-2-hydroxy-propoxy]-phenyl}-amide) 
• 106163-11-5 N,N'-Bis-{4-[3-(benzyl-isopropyl-amino)-2-hydroxy-propoxy]-phenyl}-succinamide 
• 106163-25-1 N-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-2-(4-{[4-(2-hydroxy-3-isopropylamino-propoxy)-phenylcarbamoyl]-methyl}-piperazin-1-yl)-acetamide 
• 106163-24-0 2,2'-(1,8-octanediyldiimino)bis[N-(4-{2-hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl)acetamide] 

Relevant articles and documents

Redox-Neutral Selenium-Catalysed Isomerisation of para-Hydroxamic Acids into para-Aminophenols

A selenium-catalysed para-hydroxylation of N-aryl-hydroxamic acids is reported. Mechanistically, the reaction comprises an N?O bond cleavage and consecutive selenium-induced [2,3]-rearrangement to deliver para-hydroxyaniline derivatives. The mechanism is studied through both 18O-crossover experiments as well as quantum chemical calculations. This redox-neutral transformation provides an unconventional synthetic approach to para-aminophenols.

Synthesis and pharmacological evaluation of piperidine (piperazine)-amide substituted derivatives as multi-target antipsychotics

We report the optimisation of a series of novel amide-piperidine (piperazine) derivatives using the multiple ligand approach with dopamine and serotonin receptors. Of the derivatives, compound 11 exhibited high affinity for the D2, 5-HT1A, and 5-HT2A receptors, but low affinity for the 5-HT2C and histamine H1 receptors and human ether-a-go-go-related gene (hERG) channels. In vivo, compound 11 reduced apomorphine-induced climbing, MK-801-induced hyperactivity and DOI-induced head twitching without observable catalepsy, even at the highest dose tested. In addition, it exhibited suppression in a CAR test. Furthermore, in a novel object recognition task, it displayed procognition properties. Therefore, compound 11 is a promising candidate multi-target antipsychotic.

Synthesis, anorexigenic activity and QSAR of substituted aryloxypropanolamines

Substituted aryloxypropanolamines (6-20) were synthesized and evaluated for their anorexigenic activity. Among them 4-cyanoaryloxy (7), 2-methylaryloxy (9), 2-methoxyl aryloxy (10), 4-acetamidoaryloxy (15), 4-bromoaryloxy (16) and 4-ethylaminoaryloxy (20) exhibited potent anorexigenic activity. According to QSAR studies, the electronic parameter 'σ' plays an important role in describing the variance in activity. Birkhaeuser Boston 2004.