Thiocarbonic acid O-[(2S,3S,4S,5S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O-phenyl ester

Base Information

• Chemical Name: Thiocarbonic acid O-[(2S,3S,4S,5S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O-phenyl ester
• CAS No.: 156969-24-3
• Molecular Formula: C₂₂H₂₉ClN₂O₆SSi
• Molecular Weight: 513.087

Synonyms:

Chemical Property of Thiocarbonic acid O-[(2S,3S,4S,5S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thiocarbonic acid O-[(2S,3S,4S,5S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O-phenyl ester

There total 4 articles about Thiocarbonic acid O-[(2S,3S,4S,5S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-β-L-arabinofurano[1',2':4,5]oxazoline (35939-60-7) → Thiocarbonic acid O-[(2S,3S,4S,5S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O-phenyl ester (156969-24-3)

Guidance literature:

Multi-step reaction with 3 steps

2: 86 percent / pyridine / 72 h / Ambient temperature; then reflux 2 h

3: 4-dimethylaminopyridine / acetonitrile / Ambient temperature

With pyridine; dmap; In acetonitrile;

DOI:10.1016/S0040-4039(00)73214-X

Reference yield:

(2S,3S,3aR,9aS)-3-hydroxy-2-(hydroxymethyl)-2,3,3a,9a-tetrahydro-6H-furo[2,3’:4,5]oxazolo[3,2-a]pyrimidin-6-one (31501-46-9) → Thiocarbonic acid O-[(2S,3S,4S,5S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O-phenyl ester (156969-24-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / pyridine / 72 h / Ambient temperature; then reflux 2 h

2: 4-dimethylaminopyridine / acetonitrile / Ambient temperature

With pyridine; dmap; In acetonitrile;

DOI:10.1016/S0040-4039(00)73214-X

Reference yield:

L-(+)-arabinose (87-72-9,608-45-7,608-46-8,608-47-9,2460-44-8,6748-95-4,6763-34-4,7261-26-9,7283-06-9,7283-07-0,7296-55-1,7296-56-2,7296-58-4,7296-59-5,7296-60-8,7296-61-9,7296-62-0,7322-30-7,10257-31-5,10257-32-6,10257-33-7,10257-34-8,10257-35-9,19982-83-3,20242-88-0,28697-53-2,36562-42-2,41546-41-2,89299-64-9,107655-34-5,115794-06-4,115794-07-5,130550-15-1,130606-21-2) → Thiocarbonic acid O-[(2S,3S,4S,5S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O-phenyl ester (156969-24-3)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonia / H₂O; methanol

3: 86 percent / pyridine / 72 h / Ambient temperature; then reflux 2 h

4: 4-dimethylaminopyridine / acetonitrile / Ambient temperature

With pyridine; dmap; ammonia; In methanol; water; acetonitrile;

DOI:10.1016/S0040-4039(00)73214-X

upstream raw materials:

1-[(2S,3S,4S,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-3-chloro-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

phenylcarbonochloridothioate

2-amino-β-L-arabinofurano[1',2':4,5]oxazoline

(2S,3S,3aR,9aS)-3-hydroxy-2-(hydroxymethyl)-2,3,3a,9a-tetrahydro-6H-furo[2,3’:4,5]oxazolo[3,2-a]pyrimidin-6-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 156969-24-3 Thiocarbonic acid O-[(2S,3S,4S,5S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O-phenyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send