Technology Process of (1SR,2SR,5SR,6SR)-2,6-bis-(diphenylphosphinoyl)cyclononane-1,5-diol
There total 6 articles about (1SR,2SR,5SR,6SR)-2,6-bis-(diphenylphosphinoyl)cyclononane-1,5-diol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 58 percent / peracetic acid / CH2Cl2 / 0.25 h / 9 °C
2: 1.) perchloric acid, N-bromosuccinimide, H2O, 2.) K2CO3 / 1.) acetone, 4 h, 2.) MeOH, H2O, 18 deg C, 16 h
3: 2.) H2O2, AcOH, 3.) pyridine, 4-dimethylaminopyridine, 4.) KOH
With
pyridine; peracetic acid; dmap; potassium hydroxide; N-Bromosuccinimide; perchloric acid; water; dihydrogen peroxide; potassium carbonate; acetic acid;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 89 percent / Na, liquid NH3 / diethyl ether / 2 h
2: 58 percent / peracetic acid / CH2Cl2 / 0.25 h / 9 °C
3: 1.) perchloric acid, N-bromosuccinimide, H2O, 2.) K2CO3 / 1.) acetone, 4 h, 2.) MeOH, H2O, 18 deg C, 16 h
4: 2.) H2O2, AcOH, 3.) pyridine, 4-dimethylaminopyridine, 4.) KOH
With
pyridine; peracetic acid; dmap; potassium hydroxide; N-Bromosuccinimide; perchloric acid; ammonia; water; dihydrogen peroxide; sodium; potassium carbonate; acetic acid;
In
diethyl ether; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 83 percent / methyl-lithium / diethyl ether / 1.) -78 deg C, 30 min, 2.) 18 deg C, 30 min
2: 89 percent / Na, liquid NH3 / diethyl ether / 2 h
3: 58 percent / peracetic acid / CH2Cl2 / 0.25 h / 9 °C
4: 1.) perchloric acid, N-bromosuccinimide, H2O, 2.) K2CO3 / 1.) acetone, 4 h, 2.) MeOH, H2O, 18 deg C, 16 h
5: 2.) H2O2, AcOH, 3.) pyridine, 4-dimethylaminopyridine, 4.) KOH
With
pyridine; peracetic acid; dmap; potassium hydroxide; N-Bromosuccinimide; perchloric acid; ammonia; water; methyllithium; dihydrogen peroxide; sodium; potassium carbonate; acetic acid;
In
diethyl ether; dichloromethane;
