5-butyl-1-[[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imidazole-2-carboxylic acid

Base Information

Chemical Name:5-butyl-1-[[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imidazole-2-carboxylic acid
CAS No.:163294-74-4
Molecular Formula:C₂₂H₂₂N₆O₂
Molecular Weight:402.456
Hs Code.:

Synonyms:

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Chemical Property of 5-butyl-1-[[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imidazole-2-carboxylic acid

Chemical Property:

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Technology Process of 5-butyl-1-[[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imidazole-2-carboxylic acid

There total 17 articles about 5-butyl-1-[[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imidazole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400934-09-9
C₄₁H₃₆N₆O₂

: 163294-74-4
5-butyl-1-[[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imidazole-2-carboxylic acid

Guidance literature:: With formic acid; In diethyl ether; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2012.07.040

Reference yield:

: C₁₃H₁₈BNO₂

: 163294-74-4
5-butyl-1-[[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imidazole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: toluene / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene / 4 h / 100 °C / Inert atmosphere

3.1: trimethylsilylazide; trifluoroacetic acid / 36 h / 120 °C / Sealed tube

4.1: triethylamine / dichloromethane / 1 h / 20 °C

5.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 8 h / Reflux

6.1: acetonitrile / 3 h / 70 °C / Inert atmosphere

7.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 85 °C / Sealed tube

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 8 h / Inert atmosphere; Reflux

9.1: triethylsilane; trifluoroacetic acid / dichloromethane / 1 h / 20 °C

9.2: pH 3

10.1: potassium permanganate; 18-crown-6 ether / water; acetone / 0 - 20 °C

With triethylsilane; potassium permanganate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 18-crown-6 ether; trimethylsilylazide; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; 2.1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2012.07.040

Reference yield:

: 120568-11-8
5-<4'-Methyl-1,1'-biphenyl-2-yl>-1H-tetrazole

: 163294-74-4
5-butyl-1-[[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imidazole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 1 h / 20 °C

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 8 h / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

4: sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 1 h / 20 °C

5: formic acid / diethyl ether / 2 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; N-Bromosuccinimide; formic acid; 2-methyl-but-2-ene; potassium carbonate; triethylamine; dibenzoyl peroxide; In tetrachloromethane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2012.07.040