5-Bromo-N-(2-hydroxy-1,1-dimethylethyl)-2,3-dimethoxybenzamid

Base Information

• Chemical Name: 5-Bromo-N-(2-hydroxy-1,1-dimethylethyl)-2,3-dimethoxybenzamid
• CAS No.: 129117-51-7
• Molecular Formula: C₁₃H₁₈BrNO₄
• Molecular Weight: 332.194
• Mol file: 129117-51-7.mol

Synonyms:

Chemical Property of 5-Bromo-N-(2-hydroxy-1,1-dimethylethyl)-2,3-dimethoxybenzamid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Bromo-N-(2-hydroxy-1,1-dimethylethyl)-2,3-dimethoxybenzamid

There total 1 articles about 5-Bromo-N-(2-hydroxy-1,1-dimethylethyl)-2,3-dimethoxybenzamid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2,3-dimethoxybenzoic acid (72517-23-8) → 5-Bromo-N-(2-hydroxy-1,1-dimethylethyl)-2,3-dimethoxybenzamid (129117-51-7)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / toluene / 2 h / 50 °C

2: CH₂Cl₂ / 2 h / Ambient temperature

With thionyl chloride; In dichloromethane; toluene;

DOI:10.1002/hlca.19900730221

Reference yield: 82.0%

5-Bromo-N-(2-hydroxy-1,1-dimethylethyl)-2,3-dimethoxybenzamid (129117-51-7) → 2-(5-Bromo-2,3-dimethoxyphenyl)-4,5-dihydro-4,4-dimethyloxazole (107189-00-4)

Guidance literature:

With thionyl chloride; for 0.5h; Ambient temperature;

DOI:10.1002/hlca.19900730221

Reference yield:

5-Bromo-N-(2-hydroxy-1,1-dimethylethyl)-2,3-dimethoxybenzamid (129117-51-7) → 5-chloro-2,3-dimethoxybenzoyl chloride (87964-82-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / SOCl₂ / 0.5 h / Ambient temperature

2: 1) 1.6 M BuLi, 2) Cl₃CCCl₃ / 1) THF, hexane, -78 deg C, 1 h

3: 83 percent / 2 M aq. HCl / 1 h / Heating

4: SOCl₂, DMF / toluene / 1 h / 60 °C

With hydrogenchloride; n-butyllithium; thionyl chloride; hexachloroethane; N,N-dimethyl-formamide; In toluene;

DOI:10.1002/hlca.19900730221

upstream raw materials:

5-bromo-2,3-dimethoxybenzoic acid

Downstream raw materials:

2-(5-Bromo-2,3-dimethoxyphenyl)-4,5-dihydro-4,4-dimethyloxazole

2,3-Dimethoxy-5-methylbenzoyl chloride

2,3-dimethoxy-5-methylbenzoic acid

5-chloro-2,3-dimethoxybenzoyl chloride