Piperidine-1-sulfonic acid 1-[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazol-1-yl]-1-methylsulfanyl-meth-(Z)-ylideneamide

Base Information

• Chemical Name: Piperidine-1-sulfonic acid 1-[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazol-1-yl]-1-methylsulfanyl-meth-(Z)-ylideneamide
• CAS No.: 505031-17-4
• Molecular Formula: C₂₂H₂₅ClN₄O₂S₂
• Molecular Weight: 477.051
• Mol file: 505031-17-4.mol

Synonyms:

Chemical Property of Piperidine-1-sulfonic acid 1-[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazol-1-yl]-1-methylsulfanyl-meth-(Z)-ylideneamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Piperidine-1-sulfonic acid 1-[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazol-1-yl]-1-methylsulfanyl-meth-(Z)-ylideneamide

There total 4 articles about Piperidine-1-sulfonic acid 1-[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazol-1-yl]-1-methylsulfanyl-meth-(Z)-ylideneamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperidine-1-sulfonic acid [3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazole-1-carbothioyl]-amide (505031-19-6) + methyl iodide (74-88-4) → Piperidine-1-sulfonic acid 1-[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazol-1-yl]-1-methylsulfanyl-meth-(Z)-ylideneamide (505031-17-4)

Guidance literature:

With triethylamine; In acetone; at 20 ℃; for 16h;

DOI:10.1016/j.bmcl.2005.07.054

Reference yield:

piperidine-1-sulfonyl isothiocyanate (505031-18-5) → Piperidine-1-sulfonic acid 1-[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazol-1-yl]-1-methylsulfanyl-meth-(Z)-ylideneamide (505031-17-4)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 2 h / 20 °C

2: Et₃N / acetone / 16 h / 20 °C

With triethylamine; In dichloromethane; acetone;

DOI:10.1016/j.bmcl.2005.07.054

Reference yield:

C6H10N2O2S3(2-)*2K(1+) → Piperidine-1-sulfonic acid 1-[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazol-1-yl]-1-methylsulfanyl-meth-(Z)-ylideneamide (505031-17-4)

Guidance literature:

Multi-step reaction with 3 steps

1: diphosgene / CH₂Cl₂ / 20 h / 20 °C

2: CH₂Cl₂ / 2 h / 20 °C

3: Et₃N / acetone / 16 h / 20 °C

With triethylamine; trichloromethyl chloroformate; In dichloromethane; acetone;

DOI:10.1016/j.bmcl.2005.07.054

upstream raw materials:

piperidine-1-sulfonic acid [3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazole-1-carbothioyl]-amide

methyl iodide

piperidine-1-sulfonyl isothiocyanate

piperidine-1-sulfonamide

Downstream raw materials:

N-methyl-N-[(piperidin-1-yl)sulfonyl]-3-(4-chloropheny)-4-phenyl-4,5-dihydro-(1H)-pyrazole-1-carboxamidine

Refernces