β-Hydroxyethylamide of 3,3-diphenyl-2-oxoindoline-7-carboxylic acid

Base Information

• Chemical Name: β-Hydroxyethylamide of 3,3-diphenyl-2-oxoindoline-7-carboxylic acid
• CAS No.: 78034-00-1
• Molecular Formula: C₂₃H₂₀N₂O₃
• Molecular Weight: 372.423
• Mol file: 78034-00-1.mol

Synonyms:

Chemical Property of β-Hydroxyethylamide of 3,3-diphenyl-2-oxoindoline-7-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of β-Hydroxyethylamide of 3,3-diphenyl-2-oxoindoline-7-carboxylic acid

There total 1 articles about β-Hydroxyethylamide of 3,3-diphenyl-2-oxoindoline-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

Methyl 3,3-diphenyl-2-oxo-indoline-7-carboxylate (36137-10-7) + ethanolamine (141-43-5) → β-Hydroxyethylamide of 3,3-diphenyl-2-oxoindoline-7-carboxylic acid (78034-00-1)

Guidance literature:

for 2h; Heating;

DOI:10.1007/BF01152328

Reference yield: 62.0%

β-Hydroxyethylamide of 3,3-diphenyl-2-oxoindoline-7-carboxylic acid (78034-00-1) → β-Chloroethylamide of 3,3-diphenyl-2-oxoindoline-7-carboxylic acid (78034-01-2)

Guidance literature:

With thionyl chloride; for 2h; Heating;

DOI:10.1007/BF01152328

Reference yield:

β-Hydroxyethylamide of 3,3-diphenyl-2-oxoindoline-7-carboxylic acid (78034-00-1) → β-Morpholinoethylamide of 3,3-diphenyl-2-oxoindoline-7-carboxylic acid (78034-02-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / SOCl₂ / 2 h / Heating

2: 51 percent / dioxane / 3 h / Heating

With thionyl chloride; In 1,4-dioxane;

DOI:10.1007/BF01152328

upstream raw materials:

Methyl 3,3-diphenyl-2-oxo-indoline-7-carboxylate

ethanolamine

Downstream raw materials:

β-Chloroethylamide of 3,3-diphenyl-2-oxoindoline-7-carboxylic acid

β-Morpholinoethylamide of 3,3-diphenyl-2-oxoindoline-7-carboxylic acid