2',3'-isopropylidene-5'-(1-p-anisoyl-1-(tolylsulfonyl)-2-((diphenoxyphosphinyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2-penten-3-yl)-5'-deoxyadenosine

Base Information

Chemical Name:2',3'-isopropylidene-5'-(1-p-anisoyl-1-(tolylsulfonyl)-2-((diphenoxyphosphinyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2-penten-3-yl)-5'-deoxyadenosine
CAS No.:126616-40-8
Molecular Formula:C₆₀H₆₄N₅O₁₁PSSi
Molecular Weight:1122.32
Hs Code.:

2',3'-isopropylidene-5'-(1-p-anisoyl-1-(tolylsulfonyl)-2-((diphenoxyphosphinyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2-penten-3-yl)-5'-deoxyadenosine

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Chemical Property of 2',3'-isopropylidene-5'-(1-p-anisoyl-1-(tolylsulfonyl)-2-((diphenoxyphosphinyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2-penten-3-yl)-5'-deoxyadenosine

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Technology Process of 2',3'-isopropylidene-5'-(1-p-anisoyl-1-(tolylsulfonyl)-2-((diphenoxyphosphinyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2-penten-3-yl)-5'-deoxyadenosine

There total 8 articles about 2',3'-isopropylidene-5'-(1-p-anisoyl-1-(tolylsulfonyl)-2-((diphenoxyphosphinyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2-penten-3-yl)-5'-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₆₂H₆₉N₆O₁₁PSSi

: 126616-40-8
2',3'-isopropylidene-5'-(1-p-anisoyl-1-(tolylsulfonyl)-2-((diphenoxyphosphinyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2-penten-3-yl)-5'-deoxyadenosine

Guidance literature:: With acetic acid; In ethanol; water; Ambient temperature; 5-6 h;
DOI:10.1021/jo00297a034

Reference yield:

: 58680-51-6
1-methoxy-4-(tosylmethyl)benzene

: 126616-40-8
2',3'-isopropylidene-5'-(1-p-anisoyl-1-(tolylsulfonyl)-2-((diphenoxyphosphinyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2-penten-3-yl)-5'-deoxyadenosine

Guidance literature:: Multi-step reaction with 4 steps

1: 1. n-BuLi / 1. THF, hexane, -60 deg C, 1 h 2.a) -78 deg C, 1-3 h b) -20 deg C, 30 min

2: 588 mg / dimethylformamide / 10 h / Ambient temperature

3: 627 mg / DMAP, Et₃N / acetonitrile / 0.33 h / 64 °C

4: 286 mg / HOAc / ethanol; H₂O / Ambient temperature; 5-6 h

With dmap; n-butyllithium; acetic acid; triethylamine; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00297a034

Reference yield:

: 2-[(3aR,4R,6R,6aR)-6-(6-Benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl]-4-(tert-butyl-diphenyl-silanyloxy)-butyric acid

: 126616-40-8
2',3'-isopropylidene-5'-(1-p-anisoyl-1-(tolylsulfonyl)-2-((diphenoxyphosphinyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2-penten-3-yl)-5'-deoxyadenosine

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / 1 h / Ambient temperature

2: 1. n-BuLi / 1. THF, hexane, -60 deg C, 1 h 2.a) -78 deg C, 1-3 h b) -20 deg C, 30 min

3: 588 mg / dimethylformamide / 10 h / Ambient temperature

4: 627 mg / DMAP, Et₃N / acetonitrile / 0.33 h / 64 °C

5: 286 mg / HOAc / ethanol; H₂O / Ambient temperature; 5-6 h

With dmap; n-butyllithium; thionyl chloride; acetic acid; triethylamine; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00297a034