58680-51-6

Basic information

• Product Name: Benzene, 1-methoxy-4-[[(4-methylphenyl)sulfonyl]methyl]-
• Synonyms: 4-methoxybenzyl (4-methylphenyl) sulfone;Benzene,1-methoxy-4-[[(4-methylphenyl)sulfonyl]methyl];1-methoxy-4-[(p-tolylsulfonyl)methyl]benzene;p-methoxyphenylmethyl p-tolyl sulfone;p-methoxybenzyl p-tolyl sulfone;1-methoxy-4-(tosylmethyl)benzene;4-methoxybenzyl 4'-tolyl sulfone
• CAS NO: 58680-51-6
• Molecular Formula: C15H16O3S
• Molecular Weight: 276.356
• Mol File: 58680-51-6.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: Benzene, 1-methoxy-4-[[(4-methylphenyl)sulfonyl]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-methoxy-4-[[(4-methylphenyl)sulfonyl]methyl]-(58680-51-6)
• EPA Substance Registry System: Benzene, 1-methoxy-4-[[(4-methylphenyl)sulfonyl]methyl]-(58680-51-6)

Safety Data

• Hazardous Substances Data: 58680-51-6(Hazardous Substances Data)

Upstream product

• 33533-58-3 phthalic acid mono-(4-methoxy-benzyl ester) 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 105-13-5 4-Methoxybenzyl alcohol 
• 52042-15-6 (E)-4-methoxy-S,S,S'-trioxo-Sλ⁶,S'λ⁴-dithiobenzoic acid S-p-tolyl ester 
• 1416982-07-4 1-(4-methoxyphenyl)-N,N,N-trimethylmethanaminium trifluoromethanesulfonate 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 98-59-9 p-toluenesulfonyl chloride 
• 17734-35-9 1-(4-methoxyphenyl)-N,N,N-trimethylmethanaminium iodide 
• 23730-29-2 4-methoxybenzyl 4-methylbenzenesulfinate 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 3185-99-7 Methyl p-tolyl sulfone 
• 123-11-5 4-methoxy-benzaldehyde 
• 2746-25-0 p-Methoxybenzyl bromide 

Downstream Products

• 1372861-74-9 1-methoxy-4-(1-tosylvinyl)benzene 
• 2132-62-9 4,4'-dimethoxydiphenylacetylene 
• 1563173-89-6 C₂₃H₂₂O₄S 
• 637-69-4 4-Methoxystyrene 
• 72818-30-5 Anisoyl-4-tolylsulfon 
• 126616-40-8 2',3'-isopropylidene-5'-(1-p-anisoyl-1-(tolylsulfonyl)-2-((diphenoxyphosphinyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2-penten-3-yl)-5'-deoxyadenosine 
• 126616-38-4 C₄₈H₅₁O₈PSSi 
• 126616-42-0 tert-Butyl-[5-(4-methoxy-phenyl)-3-methyl-pent-4-ynyloxy]-diphenyl-silane 
• 72457-25-1 4-(4-methoxyphenyl)butanenitrile 
• 647864-34-4 1,2-bis(p-methoxyphenyl)vinyl p-tolyl sulfone 

Relevant articles and documents

Synthesis of sulfone derivatives via palladium-catalyzed cross-coupling of benzyl trimethylammonium triflates and sulfonyl hydrazides

A palladium-catalyzed cross-coupling of benzyl trimethylammonium triflates and sulfonyl hydrazides for the synthesis of various benzyl sulfones is reported. This novel protocol shows widespread functional group tolerance, leading to the desired sulfones in moderate to excellent yields.

Visible-Light-Catalyzed in Situ Denitrogenative Sulfonylation of Sulfonylhydrazones

A photocatalyzed in situ denitrogenative sulfonylation of N-arylsulfonyl hydrazones has been developed. This transformation provides a low-carbon strategy to assemble arylalkyl sulfones in a stepwise denitrogenation/sulfonylation manner.

Sodium Arenesulfinates-Involved Sulfinate Synthesis Revisited: Improved Synthesis and Revised Reaction Mechanism

Reaction of alcohols with sodium arenesulfinates could afford either sulfones or sulfinates, and O-attack of sulfinate anions onto the in situ generated carbocation intermediates from alcohols was the previous proposed reaction mechanism in many syntheses of sulfinates. This concept, which is often used consciously or unconsciously, was revised herein by using isotopic labeling experiments and development of an improved sulfinate synthesis. The improved sulfinate synthetic protocol possesses many advantages such as a high sulfinate/sulfone selectivity, a broad substrate scope, metal-free, and mild reaction conditions. The revised reaction mechanism necessitates revision of many previous proposed reaction mechanisms in literatures.