Technology Process of p-methoxybenzyl 2-<(3S,4R)-4-acetylthio-3-bromo-2-oxoazetidin-1-yl>-2-oxoacetate
There total 6 articles about p-methoxybenzyl 2-<(3S,4R)-4-acetylthio-3-bromo-2-oxoazetidin-1-yl>-2-oxoacetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: dimethylformamide / 1 h / Ambient temperature
2: 71 percent / MCPBA / CH2Cl2 / 1 h / 5 °C
3: 1.) triisopropyl phosphite, 2.) Et3N / 1.) C6H6, reflux, 8 h, 2.) EtOAc, room temperature, 30 min
4: 1.) O3, 2.) NaHSO3, NaHCO3 / 1.) EtOAc, -76 deg C, 2.) H2O
With
triisopropyl phosphite; sodium hydrogencarbonate; ozone; sodium hydrogensulfite; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/P19940000179
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 71 percent / MCPBA / CH2Cl2 / 1 h / 5 °C
2: 1.) triisopropyl phosphite, 2.) Et3N / 1.) C6H6, reflux, 8 h, 2.) EtOAc, room temperature, 30 min
3: 1.) O3, 2.) NaHSO3, NaHCO3 / 1.) EtOAc, -76 deg C, 2.) H2O
With
triisopropyl phosphite; sodium hydrogencarbonate; ozone; sodium hydrogensulfite; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
DOI:10.1039/P19940000179
- Guidance literature:
-
Multi-step reaction with 5 steps
1: PBr3, pyridine / diethyl ether / 0.25 h
2: dimethylformamide / 1 h / Ambient temperature
3: 71 percent / MCPBA / CH2Cl2 / 1 h / 5 °C
4: 1.) triisopropyl phosphite, 2.) Et3N / 1.) C6H6, reflux, 8 h, 2.) EtOAc, room temperature, 30 min
5: 1.) O3, 2.) NaHSO3, NaHCO3 / 1.) EtOAc, -76 deg C, 2.) H2O
With
pyridine; triisopropyl phosphite; phosphorus tribromide; sodium hydrogencarbonate; ozone; sodium hydrogensulfite; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/P19940000179
