rac-2-amino-3-(dimethyl(phenyl)germyl)propionic acid ethyl ester

Base Information

Chemical Name:rac-2-amino-3-(dimethyl(phenyl)germyl)propionic acid ethyl ester
CAS No.:359766-54-4
Molecular Formula:C₁₃H₂₁GeNO₂
Molecular Weight:295.905
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Chemical Property of rac-2-amino-3-(dimethyl(phenyl)germyl)propionic acid ethyl ester

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Technology Process of rac-2-amino-3-(dimethyl(phenyl)germyl)propionic acid ethyl ester

There total 1 articles about rac-2-amino-3-(dimethyl(phenyl)germyl)propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 24486-57-5
(chlromethyl)dimethyl(phenyl)germane

: 38629-19-5
3,6-Diethoxy-2,5-dihydropyridazin

: 359766-54-4
rac-2-amino-3-(dimethyl(phenyl)germyl)propionic acid ethyl ester

Guidance literature:: With hydrogenchloride; n-butyllithium; In tetrahydrofuran; n-BuLi in hexane, -70°C, stirred for 2 h, warmed to room temp. fro 12 h, repeated twice, evapd., Kugelrohr distillation (190°C, 0.01 mbar), treated EtOH-soln. with hydrochloric acid at 0°C, stirred for 2 h at 0°C (N2); the solvent was removed in vac., dissolved in CH2Cl2, extd. with satd. Na2CO3 soln., dried over Na2SO4, evapd., distilled in a Kugelrohr apparatus (80°C, 0.01 mbar); elem. anal.;
DOI:10.1016/S0022-328X(01)00783-5

Reference yield: 43.0%

: 359766-54-4
rac-2-amino-3-(dimethyl(phenyl)germyl)propionic acid ethyl ester

: 359766-55-5
rac-2-amino-3-(dimethyl(phenyl)germyl)propionic acid

Guidance literature:: With hydrogenchloride; lithium hydroxide; methyloxirane; In 1,4-dioxane; LiOH in H2O, stirred for 16 h at room temp., evapd., ion exchanged for 30 min, pH 10-11 (aq. Et3N), filtered, treated with aq. HCl, shaken for 5 min at room temp., filtered, evapd., EtOH-soln. was treated with propylene oxide, reflux for 10 min (N2); ppt. was washed with ethanol and diethyl ether, dried in vac.; elem. anal.;
DOI:10.1016/S0022-328X(01)00783-5