2-Nitrobenzoyl azide

Base Information

• Chemical Name: 2-Nitrobenzoyl azide
• CAS No.: 1134-10-7
• Molecular Formula: C7H4N4O3
• Molecular Weight: 192.134
• DSSTox Substance ID: DTXSID40495512
• Mol file: 1134-10-7.mol

Synonyms:2-nitrobenzoyl azide;nitrobenzoylazide;1134-10-7;DTXSID40495512;AKOS009453221

Chemical Property of 2-Nitrobenzoyl azide

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 192.02834000
• Heavy Atom Count: 14
• Complexity: 292

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)N=[N+]=[N-])[N+](=O)[O-]

Technology Process of 2-Nitrobenzoyl azide

There total 11 articles about 2-Nitrobenzoyl azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-nitrobenzyl chloride (610-14-0) → 2-nitrobenzoyl azide (1134-10-7)

Guidance literature:

With sodium azide; In water; acetone; at 0 - 5 ℃; for 2h;

DOI:10.1016/j.bioorg.2020.104450

Reference yield: 72.0%

2,2-dibromo-1-(2-nitrophenyl)ethan-1-one (35928-59-7) → 2-nitrobenzoyl azide (1134-10-7)

Guidance literature:

With sodium azide; In water; acetone; Ambient temperature;

DOI:10.1055/s-1983-30274

Reference yield: 68.0%

o-nitrobenzohydrazide (606-26-8) → 2-nitrobenzoyl azide (1134-10-7)

Guidance literature:

With SHNC; In water; for 0.5h; Ambient temperature;

DOI:10.1021/jo9703820

upstream raw materials:

o-nitrobenzohydrazide

benzenediazonium sulphate

2-nitrobenzyl chloride

2,2-dibromo-1-(2-nitrophenyl)ethan-1-one

Downstream raw materials:

(2-nitro-phenyl)-carbamic acid-(4-nitro-phenyl ester)

Refernces

• 1、 Weber, Gunther,Hauptmann, Siegfried,Wilde, Horst,Mann, Gerhard. "Abbau von Aryl-methyl-ketonen zu Aroyl-aziden". . p. 191 - 192. Retrieved 1983.
• 2、 Currie, Iain,Sleebs, Brad E.. "Synthesis of Acyl Phosphoramidates Employing a Modified Staudinger Reaction". supporting information. p. 464 - 468. Retrieved 2021/02/03.
• 3、 Li, Xin-yang,Zhang, Ting-jian,Kamara, Mohamed Olounfeh,Lu, Guo-qing,Xu, Hai-li,Wang, De-pu,Meng, Fan-hao. "Discovery of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido) phenylurea-based thymidylate synthase (TS) inhibitor as a novel multi-effects antitumor drugs with minimal toxicity". . . Retrieved 2019/07/16.