2-(4-Hydroxyphenyl)-1-(piperidin-1-yl)ethan-1-one

Base Information

Chemical Name:2-(4-Hydroxyphenyl)-1-(piperidin-1-yl)ethan-1-one
CAS No.:113580-06-6
Molecular Formula:C13H17NO2
Molecular Weight:219.283
Hs Code.:
DSSTox Substance ID:DTXSID00549060
Wikidata:Q82427938

Synonyms:113580-06-6;2-(4-Hydroxyphenyl)-1-(piperidin-1-yl)ethan-1-one;SCHEMBL2236040;DTXSID00549060

Suppliers and Price of 2-(4-Hydroxyphenyl)-1-(piperidin-1-yl)ethan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 2-(4-Hydroxyphenyl)-1-(piperidin-1-yl)ethan-1-one

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:219.125928785
Heavy Atom Count:16
Complexity:228

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(CC1)C(=O)CC2=CC=C(C=C2)O

Technology Process of 2-(4-Hydroxyphenyl)-1-(piperidin-1-yl)ethan-1-one

There total 1 articles about 2-(4-Hydroxyphenyl)-1-(piperidin-1-yl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 110-89-4
piperidine

: 156-38-7
4-hydroxyphenylacetate

: 113580-06-6
2-(4-hydroxyphenyl)-1-(piperidin-1-yl)ethan-1-one

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;
DOI:10.1016/j.bmcl.2005.10.087

Reference yield: 51.0%

: 113580-06-6
2-(4-hydroxyphenyl)-1-(piperidin-1-yl)ethan-1-one

: 762-04-9
phosphonic acid diethyl ester

: diethyl (4-(2-oxo-2-(piperidin-1-yl)ethyl)phenyl) phosphate

Guidance literature:: With triethylamine; In tetrachloromethane; at 0 - 20 ℃;
DOI:10.1021/jacs.9b12519

Reference yield:

: 113580-06-6
2-(4-hydroxyphenyl)-1-(piperidin-1-yl)ethan-1-one

: 1-(piperidin-1-yl)-2-(4-(trifluoro-λ4-boraneyl)phenyl)ethan-1-one potassium salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrachloromethane / 0 - 20 °C

2.1: caesium carbonate; 10H-phenothiazine / acetonitrile / 72 h / Irradiation; Sealed tube; Inert atmosphere

2.3: 0.33 h

With 10H-phenothiazine; caesium carbonate; triethylamine; In tetrachloromethane; acetonitrile;
DOI:10.1021/jacs.9b12519