N-<(2RS,2'S)-2-<2-(benzyloxymethyl)-2-(tert-butoxycarbonylamino)ethoxy>propanoyl>-L-alanyl-D-isoglutamine benzyl ester

Base Information

• Chemical Name: N-<(2RS,2'S)-2-<2-(benzyloxymethyl)-2-(tert-butoxycarbonylamino)ethoxy>propanoyl>-L-alanyl-D-isoglutamine benzyl ester
• CAS No.: 123725-39-3
• Molecular Formula: C₃₃H₄₆N₄O₉
• Molecular Weight: 642.75
• Mol file: 123725-39-3.mol

Synonyms:

Chemical Property of N-<(2RS,2'S)-2-<2-(benzyloxymethyl)-2-(tert-butoxycarbonylamino)ethoxy>propanoyl>-L-alanyl-D-isoglutamine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<(2RS,2'S)-2-<2-(benzyloxymethyl)-2-(tert-butoxycarbonylamino)ethoxy>propanoyl>-L-alanyl-D-isoglutamine benzyl ester

There total 4 articles about N-<(2RS,2'S)-2-<2-(benzyloxymethyl)-2-(tert-butoxycarbonylamino)ethoxy>propanoyl>-L-alanyl-D-isoglutamine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-L-alanyl-D-isoglutamine benzyl ester (18814-49-8) → N-<(2RS,2'S)-2-<2-(benzyloxymethyl)-2-(tert-butoxycarbonylamino)ethoxy>propanoyl>-L-alanyl-D-isoglutamine benzyl ester (123725-39-3,123807-38-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / HCl / acetic acid / 0.5 h / Ambient temperature

2: 1) isobutyl chloroformate, triethylamine, 2) triethylamine / CH₂Cl₂, 1) -10 deg C, 20 min, 2) r.t., 8 h

With hydrogenchloride; triethylamine; isobutyl chloroformate; In acetic acid;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → N-<(2RS,2'S)-2-<2-(benzyloxymethyl)-2-(tert-butoxycarbonylamino)ethoxy>propanoyl>-L-alanyl-D-isoglutamine benzyl ester (123725-39-3,123807-38-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) KOH / 1) dioxane, H₂O, reflux, 2) 12 h, r.t.

2: 1) isobutyl chloroformate, triethylamine, 2) triethylamine / CH₂Cl₂, 1) -10 deg C, 20 min, 2) r.t., 8 h

With potassium hydroxide; triethylamine; isobutyl chloroformate;

Reference yield:

(2R,5S)-5-Benzyloxymethyl-2-methyl-3-oxoperhydro-1,4-oxazin (115206-92-3) → N-<(2RS,2'S)-2-<2-(benzyloxymethyl)-2-(tert-butoxycarbonylamino)ethoxy>propanoyl>-L-alanyl-D-isoglutamine benzyl ester (123725-39-3,123807-38-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) KOH / 1) dioxane, H₂O, reflux, 2) 12 h, r.t.

2: 1) isobutyl chloroformate, triethylamine, 2) triethylamine / CH₂Cl₂, 1) -10 deg C, 20 min, 2) r.t., 8 h

With potassium hydroxide; triethylamine; isobutyl chloroformate;

upstream raw materials:

L-alanyl-D-isoglutamine benzyl ester hydrochloride

di-tert-butyl dicarbonate

Boc-L-alanyl-D-isoglutamine benzyl ester

(2R,5S)-5-Benzyloxymethyl-2-methyl-3-oxoperhydro-1,4-oxazin

Downstream raw materials:

N-<(2RS,2'S)-2-<2-(benzyloxymethyl)-2-(hexadecanoylamino)ethoxy>propanoyl>-L-alanyl-D-isoglutamine benzyl ester

N-<(2RS,2'S)-2-<2-(benzyloxymethyl)-2-(butanoylamino)ethoxy>propanoyl>-L-alanyl-D-isoglutamine benzyl ester

N-<(2RS,2'S)-2-<2-(benzyloxymethyl)-2-(decanoylamino)ethoxy>propanoyl>-L-alanyl-D-isoglutamine benzyl ester