C₂₇H₂₇N₃O₃

Base Information

• Chemical Name: C₂₇H₂₇N₃O₃
• CAS No.: 1610360-20-7
• Molecular Formula: C₂₇H₂₇N₃O₃
• Molecular Weight: 441.53
• Mol file: 1610360-20-7.mol

Synonyms:

Chemical Property of C₂₇H₂₇N₃O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₂₇N₃O₃

There total 4 articles about C₂₇H₂₇N₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H21N3O3 (1620671-67-1) + benzaldehyde (100-52-7) → C27H27N3O3 (1610360-20-7)

Guidance literature:

C₂₀H₂₁N₃O₃; benzaldehyde; In methanol; at 20 - 60 ℃; for 6h; Molecular sieve;

With methanol; sodium cyanoborohydride; at 20 ℃; for 24h;

DOI:10.1021/jo5005795

Reference yield:

nitrostyrene (5153-67-3) → C27H27N3O3 (1610360-20-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1,4-diaza-bicyclo[2.2.2]octane / dichloromethane / 4 h / 25 °C / Inert atmosphere

2.1: hydrogen / methanol / 24 h / 20 °C

3.1: methanol / 6 h / 20 - 60 °C / Molecular sieve

3.2: 24 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogen; In methanol; dichloromethane; 1.1: |Michael Addition;

DOI:10.1021/jo5005795

Reference yield:

5-oxo-1-phenyl-2,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester (28710-96-5) → C27H27N3O3 (1610360-20-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1,4-diaza-bicyclo[2.2.2]octane / dichloromethane / 4 h / 25 °C / Inert atmosphere

2.1: hydrogen / methanol / 24 h / 20 °C

3.1: methanol / 6 h / 20 - 60 °C / Molecular sieve

3.2: 24 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogen; In methanol; dichloromethane; 1.1: |Michael Addition;

DOI:10.1021/jo5005795

upstream raw materials:

ethyl 4-(2-nitro-1-phenylethyl)-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazole-3-carboxylate

nitrostyrene

C₂₀H₂₁N₃O₃

benzaldehyde

Downstream raw materials:

6-benzyl-2,4-diphenyl-5,6-dihydro-1H-pyrazolo[3,4-c]pyridine-3,7(2H,4H)-dione