1-(2-NITROPHENYL)PYRROLE

Base Information

• Chemical Name: 1-(2-NITROPHENYL)PYRROLE
• CAS No.: 33265-60-0
• Molecular Formula: C10H8N2O2
• Molecular Weight: 188.186
• Hs Code.: 2933990090
• Mol file: 33265-60-0.mol

Synonyms:Pyrrole,1-(o-nitrophenyl)- (8CI);1-(2-Nitrophenyl)-1H-pyrrole;1-(2-Nitrophenyl)pyrrole;1-(o-Nitrophenyl)pyrrole;

Chemical Property of 1-(2-NITROPHENYL)PYRROLE

Chemical Property:

• Vapor Pressure: 0.000361mmHg at 25°C
• Melting Point: 58 °C
• Refractive Index: 1.613
• Boiling Point: 328.5 °C at 760 mmHg
• Flash Point: 152.5 °C
• PSA: 50.75000
• Density: 1.23g/cm³
• LogP: 2.90870
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-(2-Nitrophenyl)-1H-pyrrole ^*data from reagent suppliers

Safty Information:

• Safety Statements: S22:Do not inhale dust.; S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-NITROPHENYL)PYRROLE

There total 11 articles about 1-(2-NITROPHENYL)PYRROLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ 1-(2-nitrophenyl)-1H-pyrrole (33265-60-0)

Guidance literature:

Reference yield: 96.0%

cis,trans-2,5-dimethoxytetrahydrofuran (696-59-3) + 2-nitro-aniline (88-74-4) → 1-(2-nitrophenyl)-1H-pyrrole (33265-60-0)

Guidance literature:

cis,trans-2,5-dimethoxytetrahydrofuran; 2-nitro-aniline; With acetic acid; for 1h; Heating / reflux;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield: 88.0%

pyrrole (109-97-7,30604-81-0) + o-nitroiodobenzene (609-73-4) → 1-(2-nitrophenyl)-1H-pyrrole (33265-60-0)

Guidance literature:

With potassium phosphate; copper; In dimethyl sulfoxide; at 80 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.12.065

upstream raw materials:

cis,trans-2,5-dimethoxytetrahydrofuran

2-nitro-aniline

o-nitroiodobenzene

4R-4-hydroxyproline

Downstream raw materials:

1-(2-nitrophenyl)-1H-pyrrole-2-carboxylic acid

N-ethyl-1-(2-nitrophenyl)-1H-pyrrole-2-carboxamide

1-(2-nitrophenyl)-N-phenyl-1H-pyrrole-2-carboxamide

N-(4-methoxyphenyl)-1-(2-nitrophenyl)-1H-pyrrole-2-carboxamide

Refernces

• 1、 Li, Shichen,Feng, Lei,Ma, Chen. "Simple and green synthesis of benzimidazoles and pyrrolo[1,2-: A] quinoxalines via Mamedov heterocycle rearrangement". supporting information. p. 9320 - 9323. Retrieved 2021/06/14.
• 2、 Hu, Fang-Peng,Zhang, Xue-Guo,Wang, Meng,Wang, He-Song,Huang, Guo-Sheng. "Synthesis of oxazolidinones through ring-opening and annulation of vinylene carbonate with 2-pyrrolyl/indolylanilines under Rh(iii) catalysis". supporting information. p. 11980 - 11983. Retrieved 2021/12/01.