5-(CHLOROMETHYL)-N-(4-METHOXYPHENYL)-1,3,4-THIADIAZOLE-2-CARBOXAMIDE

Base Information

• Chemical Name: 5-(CHLOROMETHYL)-N-(4-METHOXYPHENYL)-1,3,4-THIADIAZOLE-2-CARBOXAMIDE
• CAS No.: 113940-15-1
• Molecular Formula: C₁₁H₁₀ClN₃O₂S
• Molecular Weight: 283.738
• Mol file: 113940-15-1.mol

Synonyms:5-Chloromethyl-[1,3,4]thiadiazole-2-carboxylic acid (4-methoxy-phenyl)-amide;

Chemical Property of 5-(CHLOROMETHYL)-N-(4-METHOXYPHENYL)-1,3,4-THIADIAZOLE-2-CARBOXAMIDE

Chemical Property:

• PSA: 92.35000
• LogP: 2.61080

Purity/Quality:

5-(Chloromethyl)-N-(4-methoxyphenyl)-1,3,4-thiadiazole-2-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(CHLOROMETHYL)-N-(4-METHOXYPHENYL)-1,3,4-THIADIAZOLE-2-CARBOXAMIDE

There total 1 articles about 5-(CHLOROMETHYL)-N-(4-METHOXYPHENYL)-1,3,4-THIADIAZOLE-2-CARBOXAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4-methoxy-phenyl)-2-morpholin-4-yl-2-thioxo-acetamide (717139-53-2) → N-(4-methoxyphenyl)-5-chloromethyl-1,3,4-thiadiazole-2-carboxamide (113940-15-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / hydrazine hydrate / dimethylformamide / 20 °C

2: 51 percent / dimethylformamide / 4 h

With hydrazine hydrate; In N,N-dimethyl-formamide;

DOI:10.1023/B:RUJO.0000010181.01921.77

Reference yield:

N-(4-methoxyphenyl)-5-chloromethyl-1,3,4-thiadiazole-2-carboxamide (113940-15-1) + methyl iodide (74-88-4) → 5-(4-Methoxy-phenylcarbamoyl)-[1,3,4]thiadiazole-2-carbodithioic acid methyl ester (118853-95-5)

Guidance literature:

With sulfur; triethylamine; Yield given. Multistep reaction; 1.) DMF, 2 h, 2.) 10 deg C;

upstream raw materials:

N-(4-methoxy-phenyl)-2-morpholin-4-yl-2-thioxo-acetamide

Downstream raw materials:

5-(4-Methoxy-phenylcarbamoyl)-[1,3,4]thiadiazole-2-carbodithioic acid methyl ester

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