N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(((3-(dimethylamino)propyl)(methyl)amino)methyl)phenyl)-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

Base Information

Chemical Name:N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(((3-(dimethylamino)propyl)(methyl)amino)methyl)phenyl)-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide
CAS No.:1396770-76-5
Molecular Formula:C₃₁H₄₁N₇O₂
Molecular Weight:543.712
Hs Code.:

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(((3-(dimethylamino)propyl)(methyl)amino)methyl)phenyl)-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

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Chemical Property of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(((3-(dimethylamino)propyl)(methyl)amino)methyl)phenyl)-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

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Technology Process of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(((3-(dimethylamino)propyl)(methyl)amino)methyl)phenyl)-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

There total 11 articles about N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(((3-(dimethylamino)propyl)(methyl)amino)methyl)phenyl)-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-cyano-2,4-dimethyl-2-hydroxypyridine

: 1396770-76-5
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(((3-(dimethylamino)propyl)(methyl)amino)methyl)phenyl)-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; ammonia / Raney Ni / methanol

2.1: dimethyl sulfoxide / 0.25 h / 20 °C

2.2: 12 h

3.1: triphenylphosphine / dichloromethane / 0.08 h / 20 °C

3.2: 1 h / 20 °C

4.1: N,N-dimethyl-formamide / 20 °C

With ammonia; hydrogen; triphenylphosphine; Raney Ni; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 771579-27-2
3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one

: 1396770-76-5
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(((3-(dimethylamino)propyl)(methyl)amino)methyl)phenyl)-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethyl sulfoxide / 0.25 h / 20 °C

1.2: 12 h

2.1: triphenylphosphine / dichloromethane / 0.08 h / 20 °C

2.2: 1 h / 20 °C

3.1: N,N-dimethyl-formamide / 20 °C

With triphenylphosphine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 6-hydroxy-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid ethyl ester

: 1396770-76-5
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(((3-(dimethylamino)propyl)(methyl)amino)methyl)phenyl)-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: phosphorus(V) oxybromide / acetonitrile / 6 h / Reflux

2.1: potassium carbonate / acetonitrile / 8 h / Reflux

3.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

4.1: dimethyl sulfoxide / 0.25 h / 20 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.17 h / Inert atmosphere

5.2: 2.17 h / 100 °C / Inert atmosphere

6.1: triphenylphosphine / dichloromethane / 0.08 h / 20 °C

6.2: 1 h / 20 °C

7.1: N,N-dimethyl-formamide / 20 °C

With water; potassium carbonate; triphenylphosphine; sodium hydroxide; phosphorus(V) oxybromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;