(4R,5R)-5-acetyl-3-((S)-2-ethoxy-1-hydroxy-2-oxoethyl)-5-(ethoxycarbonyl)-4-(4-fluorophenyl)-4,5-dihydroisoxazole 2-oxide

Base Information

• Chemical Name: (4R,5R)-5-acetyl-3-((S)-2-ethoxy-1-hydroxy-2-oxoethyl)-5-(ethoxycarbonyl)-4-(4-fluorophenyl)-4,5-dihydroisoxazole 2-oxide
• CAS No.: 1412897-10-9
• Molecular Formula: C₁₈H₂₀FNO₈
• Molecular Weight: 397.357
• Mol file: 1412897-10-9.mol

Synonyms:

Chemical Property of (4R,5R)-5-acetyl-3-((S)-2-ethoxy-1-hydroxy-2-oxoethyl)-5-(ethoxycarbonyl)-4-(4-fluorophenyl)-4,5-dihydroisoxazole 2-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5R)-5-acetyl-3-((S)-2-ethoxy-1-hydroxy-2-oxoethyl)-5-(ethoxycarbonyl)-4-(4-fluorophenyl)-4,5-dihydroisoxazole 2-oxide

There total 1 articles about (4R,5R)-5-acetyl-3-((S)-2-ethoxy-1-hydroxy-2-oxoethyl)-5-(ethoxycarbonyl)-4-(4-fluorophenyl)-4,5-dihydroisoxazole 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H12FNO5 + ethyl 2-chloro-3-oxo-butyrate (609-15-4) → (4R,5R)-5-acetyl-3-((S)-2-ethoxy-1-hydroxy-2-oxoethyl)-5-(ethoxycarbonyl)-4-(4-fluorophenyl)-4,5-dihydroisoxazole 2-oxide (1412897-10-9) + (4S,5S)-5-acetyl-3-((R)-2-ethoxy-1-hydroxy-2-oxoethyl)-5-(ethoxycarbonyl)-4-(4-fluorophenyl)-4,5-dihydroisoxazole 2-oxide

Guidance literature:

With quinindine; In dichloromethane; at -78 ℃; for 72h; Overall yield = 80 %; Overall yield = 31.8mg; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c2ob26165k DOI:10.1039/c2ob26165k

upstream raw materials:

ethyl 2-chloro-3-oxo-butyrate