(R)-4-((3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3-Benzhydryloxy-7,12-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (3-amino-propyl)-amide

Base Information

• Chemical Name: (R)-4-((3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3-Benzhydryloxy-7,12-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (3-amino-propyl)-amide
• CAS No.: 142969-86-6
• Molecular Formula: C₄₀H₅₈N₂O₄
• Molecular Weight: 630.912
• Mol file: 142969-86-6.mol

Synonyms:

Chemical Property of (R)-4-((3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3-Benzhydryloxy-7,12-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (3-amino-propyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-((3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3-Benzhydryloxy-7,12-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (3-amino-propyl)-amide

There total 4 articles about (R)-4-((3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3-Benzhydryloxy-7,12-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (3-amino-propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 7,12-diacetoxycholate (69889-89-0) → (R)-4-((3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3-Benzhydryloxy-7,12-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (3-amino-propyl)-amide (142969-86-6)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N-diisopropylethylamine / 8 h / Heating

2: sodium methoxide / methanol / 3 h / Heating

3: 3 h / Heating

With sodium methylate; N-ethyl-N,N-diisopropylamine; In methanol;

DOI:10.1021/jm00033a001

Reference yield:

Bromodiphenylmethane (776-74-9) → (R)-4-((3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3-Benzhydryloxy-7,12-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (3-amino-propyl)-amide (142969-86-6)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N-diisopropylethylamine / 8 h / Heating

2: sodium methoxide / methanol / 3 h / Heating

3: 3 h / Heating

With sodium methylate; N-ethyl-N,N-diisopropylamine; In methanol;

DOI:10.1021/jm00033a001

Reference yield:

(R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Diacetoxy-3-benzhydryloxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid methyl ester (1059673-87-8) → (R)-4-((3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3-Benzhydryloxy-7,12-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (3-amino-propyl)-amide (142969-86-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium methoxide / methanol / 3 h / Heating

2: 3 h / Heating

With sodium methylate; In methanol;

DOI:10.1021/jm00033a001

upstream raw materials:

Trimethylenediamine

(R)-4-((3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3-Benzhydryloxy-7,12-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid methyl ester

methyl 7,12-diacetoxycholate

Bromodiphenylmethane

Downstream raw materials:

C₇₁H₁₀₇N₃O₁₁