C₁₈H₂₅NO₄Si

Base Information

• Chemical Name: C₁₈H₂₅NO₄Si
• CAS No.: 1464782-28-2
• Molecular Formula: C₁₈H₂₅NO₄Si
• Molecular Weight: 347.486
• Mol file: 1464782-28-2.mol

Synonyms:

Chemical Property of C₁₈H₂₅NO₄Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₂₅NO₄Si

There total 3 articles about C₁₈H₂₅NO₄Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-ethynyl-2,2-dimethyl-[1,3]dioxan-(N-tert-butyloxycarbonyl)-5-ylamine (364631-74-3) → C18H25NO4Si (1464782-28-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 - 0 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: trimethylsilyl trifluoromethanesulfonate; 2,6-dimethylpyridine / dichloromethane / -78 °C / Inert atmosphere; Cooling with ice

2.2: Inert atmosphere

3.1: triethylamine / dichloromethane / 1 h / Inert atmosphere; Cooling with ice

With 2,6-dimethylpyridine; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; triethylamine; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1039/c3cc45099f

Reference yield:

C16H29NO4Si (1464782-07-7) → C18H25NO4Si (1464782-28-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trimethylsilyl trifluoromethanesulfonate; 2,6-dimethylpyridine / dichloromethane / -78 °C / Inert atmosphere; Cooling with ice

1.2: Inert atmosphere

2.1: triethylamine / dichloromethane / 1 h / Inert atmosphere; Cooling with ice

With 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate; triethylamine; In dichloromethane;

DOI:10.1039/c3cc45099f

Reference yield:

C11H21NO2Si (1464782-08-8) + phenyl chloroformate (1885-14-9) → C18H25NO4Si (1464782-28-2)

Guidance literature:

With triethylamine; In dichloromethane; for 1h; Inert atmosphere; Cooling with ice;

DOI:10.1039/c3cc45099f

upstream raw materials:

C₁₁H₂₁NO₂Si

phenyl chloroformate

5-ethynyl-2,2-dimethyl-[1,3]dioxan-(N-tert-butyloxycarbonyl)-5-ylamine

C₁₆H₂₉NO₄Si

Downstream raw materials:

C₁₃H₁₁NO₄

C₁₅H₂₁NO₄Si

C₁₃H₁₅NO₄

C₁₆H₁₉NO₄Si

Refernces