(E)-7-[5-(3,5-Dichloro-phenyl)-4-(4-fluoro-phenyl)-2-isopropyl-imidazol-1-yl]-5-hydroxy-3-oxo-hept-6-enoic acid methyl ester

Base Information

• Chemical Name: (E)-7-[5-(3,5-Dichloro-phenyl)-4-(4-fluoro-phenyl)-2-isopropyl-imidazol-1-yl]-5-hydroxy-3-oxo-hept-6-enoic acid methyl ester
• CAS No.: 129360-28-7
• Molecular Formula: C₂₆H₂₅Cl₂FN₂O₄
• Molecular Weight: 519.4
• Mol file: 129360-28-7.mol

Synonyms:

Chemical Property of (E)-7-[5-(3,5-Dichloro-phenyl)-4-(4-fluoro-phenyl)-2-isopropyl-imidazol-1-yl]-5-hydroxy-3-oxo-hept-6-enoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-7-[5-(3,5-Dichloro-phenyl)-4-(4-fluoro-phenyl)-2-isopropyl-imidazol-1-yl]-5-hydroxy-3-oxo-hept-6-enoic acid methyl ester

There total 1 articles about (E)-7-[5-(3,5-Dichloro-phenyl)-4-(4-fluoro-phenyl)-2-isopropyl-imidazol-1-yl]-5-hydroxy-3-oxo-hept-6-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetoacetic acid methyl ester (105-45-3) + (E)-3-[5-(3,5-Dichloro-phenyl)-4-(4-fluoro-phenyl)-2-isopropyl-imidazol-1-yl]-propenal → (E)-7-[5-(3,5-Dichloro-phenyl)-4-(4-fluoro-phenyl)-2-isopropyl-imidazol-1-yl]-5-hydroxy-3-oxo-hept-6-enoic acid methyl ester (129360-28-7)

Guidance literature:

With n-butyllithium; sodium hydride; Multistep reaction;

DOI:10.1021/jm00075a020

Reference yield:

(E)-7-[5-(3,5-Dichloro-phenyl)-4-(4-fluoro-phenyl)-2-isopropyl-imidazol-1-yl]-5-hydroxy-3-oxo-hept-6-enoic acid methyl ester (129360-28-7) → Sodium; (E)-(3S,5R)-7-[5-(3,5-dichloro-phenyl)-4-(4-fluoro-phenyl)-2-isopropyl-imidazol-1-yl]-3,5-dihydroxy-hept-6-enoate

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) methoxydiethylborane, 2.) sodium borohydride / 1.) THF, methanol, -78 deg C, 2.) THF, methanol, -78 deg C

2: aq. NaOH / tetrahydrofuran

With sodium hydroxide; sodium tetrahydroborate; diethyl methoxy borane; In tetrahydrofuran;

DOI:10.1021/jm00075a020

Reference yield:

(E)-7-[5-(3,5-Dichloro-phenyl)-4-(4-fluoro-phenyl)-2-isopropyl-imidazol-1-yl]-5-hydroxy-3-oxo-hept-6-enoic acid methyl ester (129360-28-7) → (E)-(3S,5R)-7-[5-(3,5-Dichloro-phenyl)-4-(4-fluoro-phenyl)-2-isopropyl-imidazol-1-yl]-3,5-dihydroxy-hept-6-enoic acid methyl ester

Guidance literature:

With sodium tetrahydroborate; diethyl methoxy borane; Multistep reaction; 1.) THF, methanol, -78 deg C, 2.) THF, methanol, -78 deg C;

DOI:10.1021/jm00075a020

upstream raw materials:

acetoacetic acid methyl ester