N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidylyl-(3'-5')-N²-isobutyryl-3'-O-(tert-butyldiphenylsilyl)-2'-deoxyguanosine 3'-methylphosphonate

Base Information

• Chemical Name: N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidylyl-(3'-5')-N²-isobutyryl-3'-O-(tert-butyldiphenylsilyl)-2'-deoxyguanosine 3'-methylphosphonate
• CAS No.: 183480-91-3
• Molecular Formula: C₆₈H₇₃N₈O₁₃PSi
• Molecular Weight: 1269.43

Synonyms:

Chemical Property of N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidylyl-(3'-5')-N²-isobutyryl-3'-O-(tert-butyldiphenylsilyl)-2'-deoxyguanosine 3'-methylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidylyl-(3'-5')-N²-isobutyryl-3'-O-(tert-butyldiphenylsilyl)-2'-deoxyguanosine 3'-methylphosphonate

There total 1 articles about N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidylyl-(3'-5')-N²-isobutyryl-3'-O-(tert-butyldiphenylsilyl)-2'-deoxyguanosine 3'-methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C44H51N4O7P (115147-72-3,129097-23-0,129097-24-1) + 2-N-isobutyryl-3'-O-tert-butyldiphenylsilyl-2'-deoxyguanosine (114745-19-6) → C68H73N8O13PSi + N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidylyl-(3'-5')-N2-isobutyryl-3'-O-(tert-butyldiphenylsilyl)-2'-deoxyguanosine 3'-methylphosphonate (183480-91-3)

Guidance literature:

With 1H-tetrazole; tert.-butylhydroperoxide; Multistep reaction. Title compound not separated from byproducts; 1.) acetonitrile, room temperature, 15 min, 2.) room temperature, 15 min;

Reference yield: 65.0%

N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidylyl-(3'-5')-N2-isobutyryl-3'-O-(tert-butyldiphenylsilyl)-2'-deoxyguanosine 3'-methylphosphonate (183480-91-3) → N4-benzoyl-2'-deoxycytidylyl-(3'-5')-N2-isobutyryl-3'-O(tert-butyldiphenylsilyl)-2'-deoxyguanosine 3'-methylphosphonate (183480-93-5)

Guidance literature:

With benzenesulfonic acid; In methanol; dichloromethane; for 0.25h; Ambient temperature;

Reference yield: 53.0%

N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidylyl-(3'-5')-N2-isobutyryl-3'-O-(tert-butyldiphenylsilyl)-2'-deoxyguanosine 3'-methylphosphonate (183480-91-3) → N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidylyl-(3'-5')-N2-isobutyryl-2'-deoxyguanosine 3'-methylphosphonate (183480-92-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1h; Ambient temperature;

upstream raw materials:

C₄₄H₅₁N₄O₇P

2-N-isobutyryl-3'-O-tert-butyldiphenylsilyl-2'-deoxyguanosine

Downstream raw materials:

N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidylyl-(3'-5')-N²-isobutyryl-2'-deoxyguanosine 3'-methylphosphonate

N⁴-benzoyl-2'-deoxycytidylyl-(3'-5')-N²-isobutyryl-3'-O(tert-butyldiphenylsilyl)-2'-deoxyguanosine 3'-methylphosphonate

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