N-(2-fluorophenyl)-3-phenylpropanamide

Base Information

• Chemical Name: N-(2-fluorophenyl)-3-phenylpropanamide
• CAS No.: 5215-32-7
• Molecular Formula: C₁₅H₁₄FNO
• Molecular Weight: 243.281
• DSSTox Substance ID: DTXSID601289003
• Wikidata: Q27186606
• ChEMBL ID: CHEMBL1447009
• Mol file: 5215-32-7.mol

Synonyms:N-(2-fluorophenyl)-3-phenylpropanamide;MLS000533796;CBMicro_007946;Cambridge id 6141299;CHEMBL1447009;CHEBI:108079;DTXSID601289003;HMS2278E15;SMSF0015035;N-(2-Fluorophenyl)benzenepropanamide;STK108909;AKOS002953117;CB10816;SMR000141234;BIM-0007990.P001;N~1~-(2-fluorophenyl)-3-phenylpropanamide;AO-548/14594558;SR-01000228951;SR-01000228951-1;Q27186606;5215-32-7

Chemical Property of N-(2-fluorophenyl)-3-phenylpropanamide

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 243.105942232
• Heavy Atom Count: 18
• Complexity: 263

Purity/Quality:

N-(2-FLUOROPHENYL)-3-PHENYLPROPANAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CCC(=O)NC2=CC=CC=C2F

Technology Process of N-(2-fluorophenyl)-3-phenylpropanamide

There total 1 articles about N-(2-fluorophenyl)-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 2-Fluoroaniline (348-54-9) + carbon monoxide (201230-82-2) → N-(2-fluorophenyl)-2-phenylpropanamide (1415111-54-4) + N-(2-fluorophenyl)-3-phenylpropanamide (5215-32-7)

Guidance literature:

With phosphoric acid; palladium; potassium iodide; In 1,4-dioxane; at 130 ℃; for 24h; under 30003 Torr; Overall yield = 70 %; regioselective reaction; Autoclave; Green chemistry;

DOI:10.1039/c8gc00740c

upstream raw materials:

styrene

2-Fluoroaniline

carbon monoxide