3-(4-Hydroxyphenyl)-2-(pyridin-3-yl)-1H-inden-6-ol

Base Information

Chemical Name:3-(4-Hydroxyphenyl)-2-(pyridin-3-yl)-1H-inden-6-ol
CAS No.:114584-09-7
Molecular Formula:C20H15NO2
Molecular Weight:301.345
Hs Code.:
ChEMBL ID:CHEMBL301748
DSSTox Substance ID:DTXSID50556562
Wikidata:Q82438143
Mol file:114584-09-7.mol

Synonyms:114584-09-7;3-(4-Hydroxyphenyl)-2-(pyridin-3-yl)-1H-inden-6-ol;CHEMBL301748;DTXSID50556562

Suppliers and Price of 3-(4-Hydroxyphenyl)-2-(pyridin-3-yl)-1H-inden-6-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(4-Hydroxyphenyl)-2-(pyridin-3-yl)-1H-inden-6-ol

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:301.110278721
Heavy Atom Count:23
Complexity:453

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C2=C(C=CC(=C2)O)C(=C1C3=CN=CC=C3)C4=CC=C(C=C4)O

Technology Process of 3-(4-Hydroxyphenyl)-2-(pyridin-3-yl)-1H-inden-6-ol

There total 4 articles about 3-(4-Hydroxyphenyl)-2-(pyridin-3-yl)-1H-inden-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 114584-01-9
2-(3-pyridyl)-3-(4-methoxyphenyl)-6-methoxyindene

: 114584-09-7
2-(3-pyridyl)-3-(4-hydroxyphenyl)-6-hydroxyindene

Guidance literature:: With boron dimethyl-trifluoro sulphide; In dichloromethane; at 0 ℃;
DOI:10.1021/jm00117a014

Reference yield:

: 52700-25-1
1-(4-methoxyphenyl)-2-(pyridin-3-yl)-ethanone

: 114584-09-7
2-(3-pyridyl)-3-(4-hydroxyphenyl)-6-hydroxyindene

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / sodium hydride, LiI / dimethylformamide / 40 - 50 °C

2: 48 percent / methanesulfonic acid / CH₂Cl₂ / 0.5 h / 25 °C

3: 74 percent / BF₃*S(CH₃)2 / CH₂Cl₂ / 0 °C

With boron dimethyl-trifluoro sulphide; methanesulfonic acid; sodium hydride; lithium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00117a014

Reference yield:

: 824-98-6
m-methoxybenzyl chloride

: 114584-09-7
2-(3-pyridyl)-3-(4-hydroxyphenyl)-6-hydroxyindene

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / sodium hydride, LiI / dimethylformamide / 40 - 50 °C

2: 48 percent / methanesulfonic acid / CH₂Cl₂ / 0.5 h / 25 °C

3: 74 percent / BF₃*S(CH₃)2 / CH₂Cl₂ / 0 °C

With boron dimethyl-trifluoro sulphide; methanesulfonic acid; sodium hydride; lithium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00117a014