N'-(4-bromobenzylidene)-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazide

Base Information

• Chemical Name: N'-(4-bromobenzylidene)-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazide
• CAS No.: 1499151-39-1
• Molecular Formula: C₂₅H₂₀BrN₅O₃S
• Molecular Weight: 550.436
• Mol file: 1499151-39-1.mol

Synonyms:

Chemical Property of N'-(4-bromobenzylidene)-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-(4-bromobenzylidene)-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazide

There total 8 articles about N'-(4-bromobenzylidene)-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazide (1499151-89-1) + 4-bromo-benzaldehyde (1122-91-4) → N'-(4-bromobenzylidene)-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazide (1499151-39-1)

Guidance literature:

With acetic acid; In ethanol; for 0.05h; Time; Microwave irradiation; Reflux;

DOI:10.1007/s00044-013-0879-7

Reference yield:

1,4-dihydro-4-methyl-3-phenylpyrazolo<4,3-c>-<1,2>-benzothiazine 5,5-dioxide (17833-87-3) → N'-(4-bromobenzylidene)-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazide (1499151-39-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 8 h / Reflux

2: hydrazine hydrate / ethanol / 4 h / Reflux

3: acetic acid / ethanol / 0.05 h / Microwave irradiation; Reflux

With potassium carbonate; hydrazine hydrate; acetic acid; In ethanol; acetonitrile;

DOI:10.1007/s00044-013-0879-7

Reference yield:

1,1-dioxo-2-(2-oxo-2-phenyl-ethyl)-1,2-dihydro-1λ6-benzo[d]isothiazol-3-one (15246-95-4) → N'-(4-bromobenzylidene)-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazide (1499151-39-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: methanol; sodium methylate / 0.33 h / Reflux; Inert atmosphere

2.1: sodium hydroxide / water; acetone / 0.17 h / 20 °C

2.2: 0.25 h / 20 °C / Sonication

3.1: hydrazine hydrate / ethanol / 0.33 h / Microwave irradiation; Reflux

4.1: potassium carbonate / acetonitrile / 8 h / Reflux

5.1: hydrazine hydrate / ethanol / 4 h / Reflux

6.1: acetic acid / ethanol / 0.05 h / Microwave irradiation; Reflux

With methanol; sodium methylate; potassium carbonate; hydrazine hydrate; acetic acid; sodium hydroxide; In ethanol; water; acetone; acetonitrile;

DOI:10.1007/s00044-013-0879-7

upstream raw materials:

1,4-dihydro-4-methyl-3-phenylpyrazolo<4,3-c>-<1,2>-benzothiazine 5,5-dioxide

methyl 2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetate

ethyl 2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetate

2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazide