1-<3-propyl>-2-pyrrolidinone

Base Information

Chemical Name:1-<3-propyl>-2-pyrrolidinone
CAS No.:122662-94-6
Molecular Formula:C₂₂H₂₆N₂O₃
Molecular Weight:366.46
Hs Code.:

1-<3-<N-benzyl-N-(benzyloxycarbonyl)amino>propyl>-2-pyrrolidinone

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<3-propyl>-2-pyrrolidinone

Chemical Property:

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Technology Process of 1-<3-propyl>-2-pyrrolidinone

There total 2 articles about 1-<3-propyl>-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7663-77-6
1-(3-aminopropyl)-2-pyrrolidone

: 122662-94-6
1-<3-propyl>-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / Et₃N / CH₂Cl₂ / 1.) 0 deg C, 1.5 h, 2.) rt, 15 h

2: 1.) NaH / 1.) DMF, rt, 4 h, 2.) a) 0 deg C, 2 h, b) rt, 15 h

With sodium hydride; triethylamine; In dichloromethane;
DOI:10.1021/jm00107a004

Reference yield:

: 100-39-0
benzyl bromide

: 122662-93-5
1-<3-<(benzyloxycarbonyl)amino>propyl>-2-pyrrolidinone

: 122662-94-6
1-<3-propyl>-2-pyrrolidinone

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) DMF, rt, 4 h, 2.) a) 0 deg C, 2 h, b) rt, 15 h;
DOI:10.1021/jm00107a004

Reference yield:

: 122662-94-6
1-<3-propyl>-2-pyrrolidinone

: {3-[(S)-3-((1S,2S)-2-Amino-3-cyclohexyl-1-hydroxy-propyl)-2-oxo-pyrrolidin-1-yl]-propyl}-benzyl-carbamic acid benzyl ester; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 1.5 h, 2.) -78 deg C, 5 min

2: TFA / CH₂Cl₂ / 0.75 h / Ambient temperature

With trifluoroacetic acid; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/jm00107a004