Butanoic acid, 3,4-dihydroxy-, methyl ester, (3R)-

Base Information

• Chemical Name: Butanoic acid, 3,4-dihydroxy-, methyl ester, (3R)-
• CAS No.: 114819-45-3
• Molecular Formula: C5H10O4
• Molecular Weight: 134.132
• Mol file: 114819-45-3.mol

Synonyms:.methyl (R)-3,4-dihydroxybutanoate;methyl (3R)-3,4-dihydroxysuccinate;.(R)-methyl 3,4-dihydroxybutanoate;.methyl R-3,4-dihydroxybutyrate;

Chemical Property of Butanoic acid, 3,4-dihydroxy-, methyl ester, (3R)-

Chemical Property:

• Boiling Point: 267.0±25.0 °C(Predicted)
• PKA: 13.14±0.20(Predicted)
• PSA: 66.76000
• Density: 1.220±0.06 g/cm3(Predicted)
• LogP: -1.09730

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Butanoic acid, 3,4-dihydroxy-, methyl ester, (3R)-

There total 2 articles about Butanoic acid, 3,4-dihydroxy-, methyl ester, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(R)-dimethyl malate (70681-41-3) → (R)-methyl 3,4-dihydroxybutanoate (114819-45-3)

Guidance literature:

With sodium tetrahydroborate; dimethylsulfide borane complex;

DOI:10.1021/ja00075a082

Reference yield:

methyl (3R-4-α-L-rhamnopyranosyloxy-3-hydroxy)butanoate → L-Rhamnose (3615-41-6,478518-52-4) + (R)-methyl 3,4-dihydroxybutanoate (114819-45-3)

Guidance literature:

With α-rhamnosidase; water; Enzymatic reaction;

DOI:10.1080/14786419.2018.1428593

Reference yield: 96.0%

(R)-methyl 3,4-dihydroxybutanoate (114819-45-3) + 2,2-dimethoxy-propane (77-76-9) → methyl (R)-2-(2,2-dimethyl-1,3-dioxolan-4-yl)acetate (112031-10-4)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 1.5h;

DOI:10.1055/s-0030-1258341

upstream raw materials:

(R)-dimethyl malate

Downstream raw materials:

methyl (R)-2-(2,2-dimethyl-1,3-dioxolan-4-yl)acetate

(R)-4-benzyloxy-dihydro-2(3H)-furanone

(R)-Methyl 4-benzyloxy-3-hydroxybutanoate

methyl (R)-3-hydroxy-4-(triphenylmethyl)oxybutanoate