(R)-2-(N-(2-AMino-5-cyanobenzyl)thiophene-2-sulfonaMido)-3-phenylpropyl benzenesulfonate

Base Information

Chemical Name:(R)-2-(N-(2-AMino-5-cyanobenzyl)thiophene-2-sulfonaMido)-3-phenylpropyl benzenesulfonate
CAS No.:530145-64-3
Molecular Formula:C₂₇H₂₅N₃O₅S₃
Molecular Weight:567.711
Hs Code.:
Mol file:530145-64-3.mol

Synonyms:

Suppliers and Price of (R)-2-(N-(2-AMino-5-cyanobenzyl)thiophene-2-sulfonaMido)-3-phenylpropyl benzenesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(N-(2-AMino-5-cyanobenzyl)thiophene-2-sulfonaMido)-3-phenylpropyl benzenesulfonate

Chemical Property:

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Technology Process of (R)-2-(N-(2-AMino-5-cyanobenzyl)thiophene-2-sulfonaMido)-3-phenylpropyl benzenesulfonate

There total 13 articles about (R)-2-(N-(2-AMino-5-cyanobenzyl)thiophene-2-sulfonaMido)-3-phenylpropyl benzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₁₅N₃O₃

: 530145-64-3
N-[(2-amino-5-cyanophenyl)methyl]-N-[(1R)-1-(phenylmethyl)-2-[(phenylsulphonyl)oxy]ethyl]-2-thiophenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 5 - 20 °C / Inert atmosphere; Large scale

2.1: 4-methyl-morpholine / tetrahydrofuran / 1 h / 22 - 33 °C / Inert atmosphere; Large scale

3.1: tetrahydrofuran / 12 h / 20 - 30 °C / Inert atmosphere; Large scale

3.2: Large scale

4.1: triethylamine; dmap / dichloromethane / 3 h / 20 °C / Large scale

5.1: hydrogen; palladium on activated charcoal; methanesulfonic acid

With 4-methyl-morpholine; dmap; methanesulfonic acid; palladium on activated charcoal; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/acs.oprd.8b00307

Reference yield:

: C₈H₅BrN₂O₂

: 530145-64-3
N-[(2-amino-5-cyanophenyl)methyl]-N-[(1R)-1-(phenylmethyl)-2-[(phenylsulphonyl)oxy]ethyl]-2-thiophenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide

2.1: pyridine; N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane

3.1: tetrahydrofuran / 12 h / 20 - 30 °C / Inert atmosphere; Large scale

3.2: Large scale

4.1: triethylamine; dmap / dichloromethane / 3 h / 20 °C / Large scale

5.1: hydrogen; palladium on activated charcoal; methanesulfonic acid

With pyridine; dmap; methanesulfonic acid; palladium on activated charcoal; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.oprd.8b00307

Reference yield:

: 90178-82-8
3-formyl-4-nitrobenzonitrile

: 530145-64-3
N-[(2-amino-5-cyanophenyl)methyl]-N-[(1R)-1-(phenylmethyl)-2-[(phenylsulphonyl)oxy]ethyl]-2-thiophenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: dichloromethane / 2 h / Inert atmosphere; Reflux; Large scale

2.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 5 - 20 °C / Inert atmosphere; Large scale

3.1: 4-methyl-morpholine / tetrahydrofuran / 1 h / 22 - 33 °C / Inert atmosphere; Large scale

4.1: tetrahydrofuran / 12 h / 20 - 30 °C / Inert atmosphere; Large scale

4.2: Large scale

5.1: triethylamine; dmap / dichloromethane / 3 h / 20 °C / Large scale

6.1: hydrogen; palladium on activated charcoal; methanesulfonic acid

With 4-methyl-morpholine; dmap; methanesulfonic acid; palladium on activated charcoal; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/acs.oprd.8b00307