(R)-1-<(3R,5R,6S)-6-<(1R,2R)-2-acetoxy-1-ethylbutyl>-2-methoxy-3,5-dimethyltetrahydropyran-2-yl>-3-<(5S)-5-<(2R,5R,6S)-5-benzyloxy-5-ethyl-6-methyltetrahydropyran-2-yl>-2-methoxy-5-methyltetrahydrofuran-2-yl>-3-(4-methoxybenzyloxy)prop-1-yne

Base Information

Chemical Name:(R)-1-<(3R,5R,6S)-6-<(1R,2R)-2-acetoxy-1-ethylbutyl>-2-methoxy-3,5-dimethyltetrahydropyran-2-yl>-3-<(5S)-5-<(2R,5R,6S)-5-benzyloxy-5-ethyl-6-methyltetrahydropyran-2-yl>-2-methoxy-5-methyltetrahydrofuran-2-yl>-3-(4-methoxybenzyloxy)prop-1-yne
CAS No.:113643-44-0
Molecular Formula:C₄₈H₇₀O₁₀
Molecular Weight:807.078
Hs Code.:

(R)-1-<(3R,5R,6S)-6-<(1R,2R)-2-acetoxy-1-ethylbutyl>-2-methoxy-3,5-dimethyltetrahydropyran-2-yl>-3-<(5S)-5-<(2R,5R,6S)-5-benzyloxy-5-ethyl-6-methyltetrahydropyran-2-yl>-2-methoxy-5-methyltetrahydrofuran-2-yl>-3-(4-methoxybenzyloxy)prop-1-yne

Synonyms:

Suppliers and Price of (R)-1-<(3R,5R,6S)-6-<(1R,2R)-2-acetoxy-1-ethylbutyl>-2-methoxy-3,5-dimethyltetrahydropyran-2-yl>-3-<(5S)-5-<(2R,5R,6S)-5-benzyloxy-5-ethyl-6-methyltetrahydropyran-2-yl>-2-methoxy-5-methyltetrahydrofuran-2-yl>-3-(4-methoxybenzyloxy)prop-1-yne

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-1-<(3R,5R,6S)-6-<(1R,2R)-2-acetoxy-1-ethylbutyl>-2-methoxy-3,5-dimethyltetrahydropyran-2-yl>-3-<(5S)-5-<(2R,5R,6S)-5-benzyloxy-5-ethyl-6-methyltetrahydropyran-2-yl>-2-methoxy-5-methyltetrahydrofuran-2-yl>-3-(4-methoxybenzyloxy)prop-1-yne

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-1-<(3R,5R,6S)-6-<(1R,2R)-2-acetoxy-1-ethylbutyl>-2-methoxy-3,5-dimethyltetrahydropyran-2-yl>-3-<(5S)-5-<(2R,5R,6S)-5-benzyloxy-5-ethyl-6-methyltetrahydropyran-2-yl>-2-methoxy-5-methyltetrahydrofuran-2-yl>-3-(4-methoxybenzyloxy)prop-1-yne

There total 31 articles about (R)-1-<(3R,5R,6S)-6-<(1R,2R)-2-acetoxy-1-ethylbutyl>-2-methoxy-3,5-dimethyltetrahydropyran-2-yl>-3-<(5S)-5-<(2R,5R,6S)-5-benzyloxy-5-ethyl-6-methyltetrahydropyran-2-yl>-2-methoxy-5-methyltetrahydrofuran-2-yl>-3-(4-methoxybenzyloxy)prop-1-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 113643-40-6
<(2R,5R,6S)-5-benzyloxy-5-ethyl-6-methyltetrahydropyran>-2-methanol

: 113643-44-0,113668-17-0,113668-18-1,113668-19-2
(R)-1-<(3R,5R,6S)-6-<(1R,2R)-2-acetoxy-1-ethylbutyl>-2-methoxy-3,5-dimethyltetrahydropyran-2-yl>-3-<(5S)-5-<(2R,5R,6S)-5-benzyloxy-5-ethyl-6-methyltetrahydropyran-2-yl>-2-methoxy-5-methyltetrahydrofuran-2-yl>-3-(4-methoxybenzyloxy)prop-1-yne

Guidance literature:: Multi-step reaction with 12 steps

1: CrO₃, H₂SO₄ / acetone / 0 °C

3: n-BuLi / tetrahydrofuran / -93 °C

4: 1.) NaH; 2.) H₂ / 2.) Pd-C / 1.) DMSO-THF, 0 deg C; 2.) AcOEt

5: 87 percent / diethyl ether / -93 °C

6: 96 percent / 1N-HCl / tetrahydrofuran / Ambient temperature

7: 95 percent / imidazole / CH₂Cl₂ / Ambient temperature

9: 92 percent / n-BuLi / tetrahydrofuran / -78 °C

10: 100 percent / MnO₂ / CH₂Cl₂

11: 85 percent / CSA / methanol

With 1H-imidazole; chromium(VI) oxide; hydrogenchloride; manganese(IV) oxide; n-butyllithium; sulfuric acid; camphor-10-sulfonic acid; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetone;
DOI:10.1016/S0040-4039(00)95485-6

Reference yield:

: (2R,5R,6S)-5-Benzyloxy-5-ethyl-6-methyl-tetrahydro-pyran-2-carboxylic acid

: 113643-44-0,113668-17-0,113668-18-1,113668-19-2
(R)-1-<(3R,5R,6S)-6-<(1R,2R)-2-acetoxy-1-ethylbutyl>-2-methoxy-3,5-dimethyltetrahydropyran-2-yl>-3-<(5S)-5-<(2R,5R,6S)-5-benzyloxy-5-ethyl-6-methyltetrahydropyran-2-yl>-2-methoxy-5-methyltetrahydrofuran-2-yl>-3-(4-methoxybenzyloxy)prop-1-yne

Guidance literature:: Multi-step reaction with 11 steps

2: n-BuLi / tetrahydrofuran / -93 °C

3: 1.) NaH; 2.) H₂ / 2.) Pd-C / 1.) DMSO-THF, 0 deg C; 2.) AcOEt

4: 87 percent / diethyl ether / -93 °C

5: 96 percent / 1N-HCl / tetrahydrofuran / Ambient temperature

6: 95 percent / imidazole / CH₂Cl₂ / Ambient temperature

8: 92 percent / n-BuLi / tetrahydrofuran / -78 °C

9: 100 percent / MnO₂ / CH₂Cl₂

10: 85 percent / CSA / methanol

With 1H-imidazole; hydrogenchloride; manganese(IV) oxide; n-butyllithium; camphor-10-sulfonic acid; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(00)95485-6

Reference yield:

: 107207-31-8
(2R,3R)-2,4-isopropylidenedioxy-3-(4-methoxybenzyloxy)butanol

: 113643-44-0,113668-17-0,113668-18-1,113668-19-2
(R)-1-<(3R,5R,6S)-6-<(1R,2R)-2-acetoxy-1-ethylbutyl>-2-methoxy-3,5-dimethyltetrahydropyran-2-yl>-3-<(5S)-5-<(2R,5R,6S)-5-benzyloxy-5-ethyl-6-methyltetrahydropyran-2-yl>-2-methoxy-5-methyltetrahydrofuran-2-yl>-3-(4-methoxybenzyloxy)prop-1-yne

Guidance literature:: Multi-step reaction with 10 steps

1: 100 percent / (COCl)2, Et₃N / CH₂Cl₂; dimethylsulfoxide

2: 1.) NaH; 2.) H₂ / 2.) Pd-C / 1.) DMSO-THF, 0 deg C; 2.) AcOEt

3: 87 percent / diethyl ether / -93 °C

4: 96 percent / 1N-HCl / tetrahydrofuran / Ambient temperature

5: 95 percent / imidazole / CH₂Cl₂ / Ambient temperature

7: 92 percent / n-BuLi / tetrahydrofuran / -78 °C

8: 100 percent / MnO₂ / CH₂Cl₂

9: 85 percent / CSA / methanol

With 1H-imidazole; hydrogenchloride; manganese(IV) oxide; n-butyllithium; oxalyl dichloride; camphor-10-sulfonic acid; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(00)95485-6