5'-O-monomethoxytritylthymidylyl(3',5')thymidylyl(3',5')(3'-O-acetylthymidine) di>

Base Information

• Chemical Name: 5'-O-monomethoxytritylthymidylyl(3',5')thymidylyl(3',5')(3'-O-acetylthymidine) di>
• CAS No.: 126354-82-3
• Molecular Formula: C₆₆H₆₈N₈O₂₃P₂S₂
• Molecular Weight: 1467.39
• Mol file: 126354-82-3.mol

Synonyms:

Chemical Property of 5'-O-monomethoxytritylthymidylyl(3',5')thymidylyl(3',5')(3'-O-acetylthymidine) di>

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-monomethoxytritylthymidylyl(3',5')thymidylyl(3',5')(3'-O-acetylthymidine) di>

There total 2 articles about 5'-O-monomethoxytritylthymidylyl(3',5')thymidylyl(3',5')(3'-O-acetylthymidine) di> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C29H34N5O14PS + (S)-Thiophosphoric acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(2-nitro-benzyl) ester O'-(4-nitro-phenyl) ester (126354-79-8) → 5'-O-monomethoxytritylthymidylyl(3',5')thymidylyl(3',5')(3'-O-acetylthymidine) di> (126354-82-3,126453-93-8)

Guidance literature:

With tert-butylmagnesium chloride; Yield given. Multistep reaction; 1.) pyridine, THF 2.) pyridine, room t., 8 h;

DOI:10.1016/S0040-4039(01)80667-5

Reference yield:

C29H34N5O14PS + (R)-Thiophosphoric acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(2-nitro-benzyl) ester O'-(4-nitro-phenyl) ester (126354-80-1) → 5'-O-monomethoxytritylthymidylyl(3',5')thymidylyl(3',5')(3'-O-acetylthymidine) di> (126354-82-3,126453-93-8)

Guidance literature:

With tert-butylmagnesium chloride; Yield given. Multistep reaction; 1.) pyridine, THF 2.) pyridine, room t., 18 h;

DOI:10.1016/S0040-4039(01)80667-5

Reference yield:

5'-O-monomethoxytritylthymidylyl(3',5')thymidylyl(3',5')(3'-O-acetylthymidine) di> (126354-82-3,126453-93-8) → C52H58N6O19P2S2

Guidance literature:

With thiophenol; triethylamine; In 1,4-dioxane;

DOI:10.1016/S0040-4039(01)80667-5

upstream raw materials:

(R)-Thiophosphoric acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(2-nitro-benzyl) ester O'-(4-nitro-phenyl) ester

(S)-Thiophosphoric acid O-[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(2-nitro-benzyl) ester O'-(4-nitro-phenyl) ester