trans-3-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetamido>-4-methoxycarbonyl-2-azetidinone

Base Information

Chemical Name:trans-3-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetamido>-4-methoxycarbonyl-2-azetidinone
CAS No.:84208-38-8
Molecular Formula:C₂₃H₂₃ClN₆O₁₀S
Molecular Weight:610.989
Hs Code.:

trans-3-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetamido>-4-methoxycarbonyl-2-azetidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of trans-3-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetamido>-4-methoxycarbonyl-2-azetidinone

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Technology Process of trans-3-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetamido>-4-methoxycarbonyl-2-azetidinone

There total 28 articles about trans-3-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetamido>-4-methoxycarbonyl-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 84208-37-7
2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetyl chloride hydrochloride

: 72079-37-9,84187-48-4,104159-67-3
trans-3-amino-4-methoxycarbonyl-2-azetidinone

: 84208-38-8,84276-10-8
trans-3-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetamido>-4-methoxycarbonyl-2-azetidinone

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; for 0.5h; Ambient temperature;
DOI:10.1248/cpb.32.2646

Reference yield: 77.0%

: 72079-37-9,84187-48-4,104159-67-3
cis-3-amino-4-methoxycarbonyl-2-azetidinone

: 84208-37-7
2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetyl chloride hydrochloride

: 84208-38-8,84276-10-8
cis-3-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetamido>-4-methoxycarbonyl-2-azetidinone

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; for 0.5h; Ambient temperature;
DOI:10.1248/cpb.32.2646

Reference yield:

: 61964-78-1,84187-43-9,88792-16-9,88792-17-0,88852-05-5,97591-35-0
cis-3-amino-1-(2,4-dimethoxybenzyl)-4-methoxycarbonyl-2-azetidinone

: 84208-38-8,84276-10-8
cis-3-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetamido>-4-methoxycarbonyl-2-azetidinone

Guidance literature:: Multi-step reaction with 4 steps

1: propylene oxide / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 79 percent / <1.6 molar equiv. K₂S₂O₈, K₂HPO₄ / acetonitrile; H₂O / 2 h / Heating

3: 92 percent / hydrogen / 5percent Pd-C / ethanol / 1 h / Ambient temperature

4: 77 percent / NaHCO₃ / tetrahydrofuran; H₂O / 0.5 h / Ambient temperature

With dipotassium hydrogenphosphate; dipotassium peroxodisulfate; hydrogen; sodium hydrogencarbonate; methyloxirane; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1248/cpb.32.2646