4(3H)-Quinazolinone, 3-[(acetyloxy)amino]-2-ethyl-

Base Information

• Chemical Name: 4(3H)-Quinazolinone, 3-[(acetyloxy)amino]-2-ethyl-
• CAS No.: 114914-23-7
• Molecular Formula: C12H13N3O3
• Molecular Weight: 247.254
• DSSTox Substance ID: DTXSID80451798
• Nikkaji Number: J616.993G
• Mol file: 114914-23-7.mol

Synonyms:114914-23-7;3-(Acetoxyamino)-2-ethylquinazolin-4(3H)-one;4(3H)-Quinazolinone, 3-[(acetyloxy)amino]-2-ethyl-;DTXSID80451798;(2-ethyl-4-oxo-3,4-dihydroquinazolin-3-yl)amino acetate

Chemical Property of 4(3H)-Quinazolinone, 3-[(acetyloxy)amino]-2-ethyl-

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 247.09569129
• Heavy Atom Count: 18
• Complexity: 381

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCC1=NC2=CC=CC=C2C(=O)N1NOC(=O)C

Technology Process of 4(3H)-Quinazolinone, 3-[(acetyloxy)amino]-2-ethyl-

There total 1 articles about 4(3H)-Quinazolinone, 3-[(acetyloxy)amino]-2-ethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

lead(IV) tetraacetate (546-67-8) + 3-amino-2-ethylquinazoline-4(3H)-one (50547-51-8) → 2-ethyl-3H-quinazolin-4-one (3137-64-2) + 3-(acetoxyamino)-2-ethylquinazolin-4(3H)-one (114914-23-7)

Guidance literature:

In chloroform-d1; at -20 ℃; Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(01)80116-2

Reference yield: 86.0%

styryltrimethylsilane (18001-47-3) + 3-(acetoxyamino)-2-ethylquinazolin-4(3H)-one (114914-23-7) → 2-Ethyl-3-(2-phenyl-3-trimethylsilanyl-aziridin-1-yl)-3H-quinazolin-4-one

Guidance literature:

In dichloromethane;

DOI:10.1039/c39890000836

Reference yield: 83.0%

3-(acetoxyamino)-2-ethylquinazolin-4(3H)-one (114914-23-7) + 2-Ethyl-3-{(2R,3S)-4-oxo-2-phenyl-5-[1-phenyl-meth-(E)-ylidene]-1-aza-spiro[2.5]oct-1-yl}-3H-quinazolin-4-one → (2R,3S,5S,7R)-1,6-Bis-(2-ethyl-4-oxo-4H-quinazolin-3-yl)-2,7-diphenyl-1,6-diaza-dispiro[2.1.2.3]decan-4-one

Guidance literature:

In dichloromethane; for 1h; Ambient temperature;

DOI:10.3987/com-97-7798

upstream raw materials:

lead(IV) tetraacetate

3-amino-2-ethylquinazoline-4(3H)-one

Downstream raw materials:

2-ethyl-3H-quinazolin-4-one

7-(2-ethyl-3,4-dihydro-4-oxoquinazolin-3-yl)-2β-methoxy-7-azabicyclo<4.1.0>heptane

2β-acetoxy-7-(2-ethyl-3,4-dihydro-4-oxoquinazolin-3-yl)-7-azabicyclo<4.1.0>heptane

7-(2-ethyl-3,4-dihydro-4-oxoquinazolin-3-yl)-5α-hydroxy-1-phenyl-7-azabicyclo<4.1.0>heptane