4,5-Dichloro-2-(trifluoromethyl)phenol

Base Information

Chemical Name:4,5-Dichloro-2-(trifluoromethyl)phenol
CAS No.:51571-02-9
Molecular Formula:C₇H₃Cl₂F₃O
Molecular Weight:231.001
Hs Code.:
DSSTox Substance ID:DTXSID301282260

Synonyms:4,5-dichloro-2-(trifluoromethyl)phenol;51571-02-9;AIPQWROTRIUBLU-UHFFFAOYSA-N;DTXSID301282260;FT-0712295

Suppliers and Price of 4,5-Dichloro-2-(trifluoromethyl)phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4,5-Dichloro-2-(trifluoromethyl)phenol

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:229.9513046
Heavy Atom Count:13
Complexity:185

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=C(C(=CC(=C1Cl)Cl)O)C(F)(F)F

Technology Process of 4,5-Dichloro-2-(trifluoromethyl)phenol

There total 4 articles about 4,5-Dichloro-2-(trifluoromethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121-17-5
2-chloro-3-nitro-5-trifluoromethylbenzene

: 51571-02-9
4,5-dichloro-2-(trifluoromethyl)phenol

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / NH₄Cl, Zn / H₂O; ethanol / 0.5 h / Heating

2: 22 percent / 1.8N H₂SO₄, CO₂ / 0.75 h / 80 - 85 °C

3: 1.) 3.2 N HCl, NaNO₂, 2.) Cu₂Cl₂, conc. HCl / 1.) H₂O, 0 - 5 deg C, 2.) H₂O, 80 - 85 deg C, 1 h

With copper(I) chloride; hydrogenchloride; carbon dioxide; sulfuric acid; ammonium chloride; zinc; sodium nitrite; In ethanol; water;
DOI:10.1021/jm00186a024

Reference yield:

: 51571-01-8
4-amino-3-chloro-6-(trifluoromethyl)phenol

: 51571-02-9
4,5-dichloro-2-(trifluoromethyl)phenol

Guidance literature:: With copper(I) chloride; hydrogenchloride; sodium nitrite; Yield given. Multistep reaction; 1.) H₂O, 0 - 5 deg C, 2.) H₂O, 80 - 85 deg C, 1 h;
DOI:10.1021/jm00186a024

Reference yield:

: 51571-00-7
N-<2-chloro-5-(trifluoromethyl)phenyl>hydroxylamine

: 51571-02-9
4,5-dichloro-2-(trifluoromethyl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1: 22 percent / 1.8N H₂SO₄, CO₂ / 0.75 h / 80 - 85 °C

2: 1.) 3.2 N HCl, NaNO₂, 2.) Cu₂Cl₂, conc. HCl / 1.) H₂O, 0 - 5 deg C, 2.) H₂O, 80 - 85 deg C, 1 h

With copper(I) chloride; hydrogenchloride; carbon dioxide; sulfuric acid; sodium nitrite;
DOI:10.1021/jm00186a024