Methyl 3-[4-(benzyloxy)phenyl]prop-2-ynoate

Base Information

Chemical Name:Methyl 3-[4-(benzyloxy)phenyl]prop-2-ynoate
CAS No.:114943-74-7
Molecular Formula:C17H14O3
Molecular Weight:266.296
Hs Code.:
DSSTox Substance ID:DTXSID30555770
Wikidata:Q82437180

Synonyms:114943-74-7;Methyl 3-[4-(benzyloxy)phenyl]prop-2-ynoate;SCHEMBL9202331;DTXSID30555770

Suppliers and Price of Methyl 3-[4-(benzyloxy)phenyl]prop-2-ynoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 3-[4-(benzyloxy)phenyl]prop-2-ynoate

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:266.094294304
Heavy Atom Count:20
Complexity:362

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C#CC1=CC=C(C=C1)OCC2=CC=CC=C2

Technology Process of Methyl 3-[4-(benzyloxy)phenyl]prop-2-ynoate

There total 5 articles about Methyl 3-[4-(benzyloxy)phenyl]prop-2-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 705939-73-7
methyl 3-[4-(benzyloxy)phenyl]-3-oxopropanoate

: 114943-74-7
methyl 3-(4-benzyloxyphenyl)propiolate

Guidance literature:: With trifluoromethanesulfonic acid anhydride; triethylamine; Triphenylphosphine oxide; In 1,2-dichloro-ethane; at 0 ℃; for 2.25h; Heating / reflux;

Reference yield:

: 19578-68-8
4-(4-benzyloxyphenyl) iodide

: 922-67-8
propynoic acid methyl ester

: 114943-74-7
methyl 3-(4-benzyloxyphenyl)propiolate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; In 1,2-dimethoxyethane; at 70 ℃; for 12h; Inert atmosphere; Schlenk technique;
DOI:10.1002/anie.202006096

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 114943-74-7
methyl 3-(4-benzyloxyphenyl)propiolate

Guidance literature:: Multi-step reaction with 2 steps

1: Ph₃P / CH₂Cl₂

2: BuLi / tetrahydrofuran

With n-butyllithium; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-1994-25402