1-butyl-3-[4-(1-methyl-2,5-dioxopyrrolidin-3-yl)phenyl]-1-nitrosourea

Base Information

• Chemical Name: 1-butyl-3-[4-(1-methyl-2,5-dioxopyrrolidin-3-yl)phenyl]-1-nitrosourea
• CAS No.: 72676-69-8
• Molecular Formula: C16H20 N4 O4
• Molecular Weight: 332.3544
• Mol file: 72676-69-8.mol

Synonyms:NSC 312031

Chemical Property of 1-butyl-3-[4-(1-methyl-2,5-dioxopyrrolidin-3-yl)phenyl]-1-nitrosourea

Chemical Property:

• Density: 1.32g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-butyl-3-[4-(1-methyl-2,5-dioxopyrrolidin-3-yl)phenyl]-1-nitrosourea

There total 3 articles about 1-butyl-3-[4-(1-methyl-2,5-dioxopyrrolidin-3-yl)phenyl]-1-nitrosourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

1-Butyl-3-[4-(1-methyl-2,5-dioxo-pyrrolidin-3-yl)-phenyl]-urea (72676-64-3) → C16H20N4O4 (72676-69-8)

Guidance literature:

With formic acid; sodium nitrite; at 0 - 5 ℃; for 0.5h;

DOI:10.1021/jm00177a024

Reference yield:

2-(p-aminophenyl)-N-methylsuccinimide (59512-13-9) → C16H20N4O4 (72676-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / CHCl₃ / 2 h / Ambient temperature

2: 57 percent / 99percent HCOOH, NaNO₂ / 0.5 h / 0 - 5 °C

With formic acid; sodium nitrite; In chloroform;

DOI:10.1021/jm00177a024

Reference yield:

n-butyl isocyanide (111-36-4) → C16H20N4O4 (72676-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / CHCl₃ / 2 h / Ambient temperature

2: 57 percent / 99percent HCOOH, NaNO₂ / 0.5 h / 0 - 5 °C

With formic acid; sodium nitrite; In chloroform;

DOI:10.1021/jm00177a024

upstream raw materials:

1-Butyl-3-[4-(1-methyl-2,5-dioxo-pyrrolidin-3-yl)-phenyl]-urea

2-(p-aminophenyl)-N-methylsuccinimide

n-butyl isocyanide

Refernces