methyl [3-hydroxy-2-oxo-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-3-(trifluoromethyl)-2,3-dihydro-1H-indol-1-yl]acetate

Base Information

Chemical Name:methyl [3-hydroxy-2-oxo-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-3-(trifluoromethyl)-2,3-dihydro-1H-indol-1-yl]acetate
CAS No.:147749-06-2
Molecular Formula:C₁₅H₁₀F₉NO₅
Molecular Weight:455.234
Hs Code.:
Mol file:147749-06-2.mol

methyl [3-hydroxy-2-oxo-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-3-(trifluoromethyl)-2,3-dihydro-1H-indol-1-yl]acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl [3-hydroxy-2-oxo-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-3-(trifluoromethyl)-2,3-dihydro-1H-indol-1-yl]acetate

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Technology Process of methyl [3-hydroxy-2-oxo-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-3-(trifluoromethyl)-2,3-dihydro-1H-indol-1-yl]acetate

There total 2 articles about methyl [3-hydroxy-2-oxo-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-3-(trifluoromethyl)-2,3-dihydro-1H-indol-1-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 13089-11-7
methyl 3,3,3-trifluoropyruvate

: 147749-01-7
N-<4-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)phenyl>glycine methyl ester

: 147749-06-2
5-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)-3-hydroxy-1-methoxycarbonylmethyl-2-oxo-3-trifluoromethylindoline

Guidance literature:: In 1,1,2-Trichloro-1,2,2-trifluoroethane; at 120 ℃; for 6h;
DOI:10.1007/BF00864339

Reference yield:

: 23284-84-6
N-phenylglycine methyl ester

: 147749-06-2
5-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)-3-hydroxy-1-methoxycarbonylmethyl-2-oxo-3-trifluoromethylindoline

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / 1,1,2-trichloro-1,2,2-trifluoro-ethane / 8 h / 20 °C

2: 90 percent / 1,1,2-trichloro-1,2,2-trifluoro-ethane / 6 h / 120 °C

In 1,1,2-Trichloro-1,2,2-trifluoroethane;
DOI:10.1007/BF00864339